Jain Lab

Rare neurodegenerative diseases have been linked to excessive repeats in the DNA sequence. Whitehead Institute Member Ankur Jain and colleagues have uncovered a new mechanism that explains how an expanded CAG repeat — like the one involved in Huntington’s disease — can lead to the production of abnormal proteins, disrupting cell function.

Once considered genomic “junk,” repetitive sequences in DNA are being discovered to have important roles in our biology. Whitehead Institute researchers are investigating different types of these repeated sequences, from repetitive DNA regions to excessive repeats within genes, in order to understand what roles they play in cells and how they contribute to health and disease.

Whitehead Institute researchers are making discoveries that are helping us rethink what we know about the brain and paving the way for therapies to treat some of the most challenging brain disorders and diseases.

Read about brain-related research at Whitehead Institute.

Whitehead Institute researchers are studying how cells respond to stress, including dramatic shifts in temperature and in the availability of food and water. This knowledge is needed to develop approaches to protect human wellbeing in a changing climate.

Clumps of abnormal RNA are known to build up in some neurological disorders including Huntington’s disease and ALS. New research from Whitehead Institute Member Ankur Jain shows that these clumps can form outside of the cell’s nucleus, becoming more toxic to cells.

The Pew Charitable Trusts has selected Whitehead Institute Member Ankur Jain to be a 2022 Pew Scholar in the Biomedical Sciences. The Pew program provides funding to young investigators of outstanding promise who work in areas of science relevant to the advancement of human health.

Anh Nguyen is a postdoc in Whitehead Institute Member Ankur Jain’s lab studying molecules in soil-dwelling amoebae that, in humans, can contribute to neurodegenerative diseases. We sat down with Nguyen to learn more about her and her experiences in and out of the lab.