Corradin Lab

Researchers at Whitehead Institute are developing models and approaches that capture more of the rich context in which biological processes are typically immersed, in order to learn more about them and their roles in health and disease. Learn more about how their work is revealing new insights that only become apparent when studying a process within the context of larger systems in which it operates.

Science in 60 breaks down the latest research at Whitehead Institute through one-minute explainers. In this video, Xochitl Luna discusses investigating the role of microglia—the brain’s resident immune cells—in multiple sclerosis.

Biological sex is a potent modifier of health. Yet, for decades, science has overlooked conditions that disproportionately affect women. Now researchers at Whitehead Institute are challenging the status quo and making strides to understand — and transform — key aspects of women’s health.

Whitehead Institute Member Olivia Corradin and colleagues have developed a system to find patterns in seemingly random differences between the genomes of people affected and unaffected by a disease. They can use these patterns to identify genes that contribute to complex diseases and disorders, such as opioid use disorder.

Pavana Rotti is a postdoc in Whitehead Institute Member Olivia Corradin’s lab studying the neurobiology of opioid use disorder. We sat down with Pavana to learn more about her and her experiences in and out of the lab.

Whitehead Institute researchers are making discoveries that are helping us rethink what we know about the brain and paving the way for therapies to treat some of the most challenging brain disorders and diseases.

Read about brain-related research at Whitehead Institute.

A group of researchers from multiple universities, including Whitehead Institute Member Olivia Corradin, gained new insights into the genetics of opioid overdose risk by looking at changes in gene regulation in the brain.

Whitehead Institute director Ruth Lehmann announced the appointment of two dynamic new Members: Olivia Corradin, currently a Whitehead Fellow, and Siniša Hrvatin, currently an instructor and postdoctoral fellow at Harvard Medical School.