Tag: Page Lab

Whitehead Institute in the running for STAT Madness

March 2, 2020

Research on sex differences goes head to head with other discoveries in March Madness-style bracket.

Group photo of Brit d’Arbeloff and David Page (both seated) with Page lab postdoctoral fellow Adrianna San Roman (left) and Sahin Naqvi (rear), then a Page lab graduate student and now a postdoctoral fellow at Stanford University.

Whitehead Institute Receives $10 Million Gift to Study Sex Chromosomes’ Impact on Women's Health and Disease

January 9, 2020

The gift establishes the Brit Jepson d’Arbeloff Center on Women's Health within the Institute’s Sex Differences in Health and Disease Initiative

Collage of various pets of people at Whitehead Institute

Beyond the Lab Bench: A Look at the Traditions That Make Whitehead Institute Unique

December 10, 2019

The Pets of Whitehead Institute: how pets can keep people working in science tied to the larger world

Embryonic testis with PGCs in red

Committed to reproduction

November 21, 2019

Whitehead Institute researchers have rewritten the timeline for when and how embryonic cells commit to becoming sex cells, the cells that produce eggs and sperm, and gained insights into the development of testicular cancer.

Image of methylation in mouse embryos

Epigenetics: Chemical guideposts for gene expression

September 30, 2019

Whitehead Institute researchers investigate methylation, the chemical tags that help define gene expression during development and disease

Photo showing the bell curve of women's and men's heights

Genetic study takes sex differences research to new heights

July 18, 2019

Researchers find differences in gene expression between males and females throughout the body in humans and other mammals, including ones that contribute to the average height difference between the sexes

Illustration of egg with sperm swimming toward it

A troubling inheritance

April 9, 2019

Researchers have found that certain epigenetic changes in mice that appear to be inherited by offspring can lead to increased cancer rates

Immunofluorescence microscopy for meiotic markers in adult mouse testes

Start signal for sex cell creation

February 27, 2019

One protein is responsible for regulating a large network of genes that prompt cells to begin meiosis, the type of cell division that produces sex cells

Illustration of the Y chromosome

The Y Chromosome: Holding steadfast in a sea of change

August 2, 2018

The lab of Whitehead Member David Page has examined a series of regions on the Y chromosome called amplicons.

Image of mouse spermatocyte, which is the source of retinoic acid

Retinoic acid regulates transitions in mouse sperm production

November 7, 2017

Researchers swimming upstream in reproductive technology work now have important insights into sperm production

Detailed depiction of the structure of the mouse Y chromosome

What’s mighty about the mouse? For starters, its massive Y chromosome

October 30, 2014

An exhaustive effort to sequence the mouse Y chromosome reveals a surprisingly large and complex biological beast, at the same time providing remarkable insight into a heated battle for supremacy between mammalian sex chromosomes.

From liability to viability: Genes on the Y chromosome prove essential for male survival

April 23, 2014

The human Y chromosome has over the course of millions of years of evolution managed to preserve a small set of genes that has ensured not only its own survival but also the survival of men. Moreover, the vast majority of these tenacious genes appear to have little if any role in sex determination or sperm production. Taken together, these remarkable finding suggest that because these Y-linked genes are active across the body, they may actually be contributing to differences in disease susceptibility and severity observed between men and women.

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