Tag: Cheeseman Lab

Image of a cell in anaphase

Of highways, engines, and chromosomes

November 16, 2017

Whitehead researchers unravel fundamental molecular machinery that propels chromosome movement

Model for the architecture of the CCAN

Architecture of protein complex hints at its foundational function in chromosome segregation

November 19, 2015

The Constitutive Centromere-Associated Network (CCAN) plays a foundational role in the machine that directs chromosome segregation during cell division. On the left is a model of the complete machine (the kinetochore) attached to the microtubule that provides the power for chromosome segregation. The right side depicts the direct interactions between CCAN sub-complexes based on Whitehead scientists’ research as viewed from above the CENP-A nucleosome, either occuring on a single nucleosome (top) or or between two nucleosomes (bottom).”

Images of cells with normal and abnormal CENP-A deposition

Faithful cell division requires tightly controlled protein placement at the centromeres

July 17, 2014

The protein CENP-A, which is integrated into human DNA at the centromere on each chromosome, has a vital role in cell division. Work from Whitehead Institute Member Iain Cheeseman’s lab describes how the vital and tightly controlled replenishment of CENP-A progresses.

Image showing how a cell with a misaligned spindle corrects the problem

Bearing witness to the phenomenon of symmetric cell division

July 18, 2013

For more than 125 years, scientists have been peering through microscopes, carefully watching cells divide. Until now, however, none has actually seen how cells manage to divide precisely into two equally-sized daughter cells during mitosis. Such perfect division depends on the position of the mitotic spindle (chromosomes, microtubules, and spindle poles) within the cell, and it’s now clear that human cells employ two specific mechanisms during the portion of division known as anaphase to correct mitotic spindle positioning.

Diagram of how chromosomes are aligned

A mitosis mystery solved: how chromosomes align perfectly in a dividing cell

February 12, 2012

Although the process of mitotic cell division has been studied intensely for more than 50 years, Whitehead Institute researchers have only now solved the mystery of how cells correctly align their chromosomes during symmetric mitosis. 

Two unsuspected proteins may hold the key to creating artificial chromosomes

April 28, 2011

Whitehead Institute scientists report that two proteins once thought to have only supporting roles, are the true “stars” of the kinetochore assembly process in human cells.

Whitehead Member Iain Cheeseman to receive R.R. Bensley Award

December 6, 2010

Whitehead Institute Member Iain Cheeseman will receive the 2011 R.R. Bensley Award, one of four Young Investigator Awards distributed by the American Association of Anatomists (AAA).

How microtubules let go of their attachments during cell division

May 13, 2010

Whitehead Institute researchers have determined a key part of how cells regulate the chromosome/microtubule interface, which is central to proper chromosomal distribution during cell division.

Whitehead Member Iain Cheeseman awarded Young Investigator grant

April 4, 2010

Whitehead Member Iain Cheeseman has been awarded a Young Investigator grant from the Human Frontier Science Program (HFSP). The grant will fund a team including Cheeseman to study how a structural scaffold of proteins, called the spindle matrix, prepares a cell for cell division.

Whitehead Member Iain Cheeseman named Searle Scholar

May 11, 2009

Whitehead Member Iain Cheeseman has been selected as a 2009 Searle Scholar. He is one of 15 award recipients chosen from 178 recently appointed assistant professors in the chemical and biological sciences.

New Whitehead Member Iain Cheeseman to study key mechanism in cell division

June 21, 2007

His work focuses on the kinetochore, a structure that helps to divvy up DNA molecules shortly before cells divide.

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