Tag: Protein Function

Image of structure of the raptor - rag - ragulator protein comples

Whitehead Institute team resolves structure of master growth regulator

October 10, 2019

New paper in Science reveals how mTORC1 docks at lysosomal surface  


Illustration of a hairpin loop from a pre-mRNA

Regulatory RNA: The sculptors of gene expression

September 30, 2019

Whitehead Institute scientists have been uncovering the roles of regulatory RNA in controlling gene expression

Illustration of scientist letting genie DNA out of a pot

Looking Beyond the Gene: An Introduction

September 30, 2019

Whitehead Institute researchers are uncovering new ways that genes are regulated that upend existing paradigms of gene expression and provide important insights into health and disease. This collection of stories and multimedia explores that research.

Illustration of moths around a light

Signaling factor seeking gene

September 25, 2019

Whitehead Institute researchers have discovered that particular signaling pathways, which transmit environmental cues and effect changes in gene expression, rely on phase-separated condensates to find, occupy, and activate the right genes in each cell type

Illustration of scientist cutting a cell in half with a pizza cutter

To divide or not to divide?

August 15, 2019

Whitehead Institute team reveals molecular program that controls cells’ capacity for division

Collage of images in regeneration piece: Planarians, liver cells, and stem cells

The science of self-repair: regeneration research at Whitehead Institute

June 17, 2019

Researchers at Whitehead Institute are uncovering the underlying genetics, mechanisms, and principles of regeneration. 

Photo of Whitehead Institute Postdoc Izabella Pena

Whitehead Institute Postdoc Izabella Pena Selected as a 2019 Pew Latin American Fellow

June 10, 2019

Pena, who hails from Brazil, studies in Whitehead Institute Member David Sabatini's lab how cells calibrate their growth, metabolism, and proliferation based on nutrient availability 

Illustration of a mitochondrion

Drug-resistant cancer cells create own Achilles heel

May 27, 2019

Whitehead Institute and Broad Institute researchers determine that cancer cells commonly change their energy source, creating a weakness that the drug elesclomol exploits to resensitize cancer cells to proteasome inhibitors

Whitehead Institute Member Pulin Li

Pulin Li joins Whitehead Institute

April 2, 2019

Whitehead Institute announced today that the developmental and synthetic biologist Pulin Li will join the Institute in May as its newest Member. 

Immunofluorescence microscopy for meiotic markers in adult mouse testes

Start signal for sex cell creation

February 27, 2019

One protein is responsible for regulating a large network of genes that prompt cells to begin meiosis, the type of cell division that produces sex cells

Toxoplasma gondii (T. gondii) cells lose form and fail to replicate after degradation of GAPM proteins.

How one parasite stays in shape

January 23, 2019

Researchers in Whitehead Institute Member Sebastian Lourido’s lab identify the linchpin proteins of parasite Toxoplasma gondii’s cytoskeleton.

Pollen grains

A tough case cracked

December 17, 2018

The detailed molecular structure of the inert plant material sporopollenin — key for the emergence of land plants — has been resolved

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