Tag: Protein Function

Illustration of neighborhoods within DNA loops

New study prompts rethinking transcription factor’s role in control of gene expression

December 7, 2017

Like proteins, genomes must fold appropriately to function properly; some transcription factors provide the structural support

Image of a cell in anaphase

Of highways, engines, and chromosomes

November 16, 2017

Whitehead researchers unravel fundamental molecular machinery that propels chromosome movement

Illustration of scientist opening a cell and looking at a molecule

Key nutrient sensor identified for cellular pathway linking nutrient availability to cell growth

November 9, 2017

Whitehead Member David Sabatini has identified the methionine sensor in the mTOR pathway, which is a crucial metabolic pathway in cells. His work provides interesting data suggesting that the anti-aging and anti-diabetes effects of low methionine and mTOR inhibition may be connected.

Image of red algae and Roland Kersten on Ventura beach

A new workflow for natural product characterization comes ashore with red algae

October 30, 2017

Whitehead Member Jing-Ke Weng uses an omics-based path for identifying and generating sesquiterpene-based therapeutics at scale.

Image of a breast cancer cell

Stuck on the membrane: A pro-metastatic transcription factor’s journey from anonymity to a promising target for breast cancer therapy

October 20, 2017

Whitehead Member Piyush Gupta has identified a protein stuck in the cell membrane that plays an important role in a cellular pathway crucial for cancer metastasis. The protein is a potential new target for breast cancer therapy that targets the cancer cells' metastatic behavior. 

Illustration of scientist measuring a cell on a scale

Study reveals key molecular link in major cell growth pathway

October 19, 2017

A team of scientists led by Whitehead Institute has uncovered a surprising molecular link that connects how cells regulate growth with how they sense and make available the nutrients required for growth.  The researchers’ findings also implicate a new protein, SLC38A9, as a potential drug target in pancreatic cancer. 

AudioHelicase logo and Whitehead Member David Sabatini

AudioHelicase: The podcast of Whitehead Institute

September 12, 2017

Whitehead's David Sabatini discusses mTOR, a protein connecting metabolism, nutrition, and disease and the current research in his lab investigating the mTOR pathway and its role in cancer, diabetes, and aging.

Slide of red blood cells

Mystery solved: how thyroid hormone prods red blood cell production

September 5, 2017

For more than a century, the link between thyroid hormone and red blood cell production has remained elusive. Now, Whitehead scientists have teased about the mechanism that connects them, which could help scientists identify new therapies for specific types of anemia.

Diagram of how the control of the translation of mRNAs into proteins shifts as the egg becomes an the embryo

Elegant switch controls translation in transition from egg to embryo

June 14, 2017

The transition from an egg to a developing embryo is one of life’s most remarkable transformations. Now Whitehead Institute researchers have used fruit flies to decipher how one aspect—control of the translation of messenger RNAs (mRNAs) into proteins—shifts as the egg becomes an the embryo.  This type of switch could tell scientists more about how human cells work and embryos develop.

Rohgerry Deshycka, Harvey Lodish, Nova Pishesha

Undergraduate in Lodish lab doubly awarded for “outstanding” research

May 25, 2017

Rhogerry “Gerry” Deshycka, a graduating senior working in the lab of Whitehead Institute Founding Member Harvey Lodish, has received one of MIT’s two Randolph G. Wei Undergraduate Research Opportunities Program (UROP) awards for 2017 and MIT’s 2017 John L. Asinari Award

Whitehead Member David Sabatini

Whitehead Member David Sabatini awarded Foundation for the NIH Lurie Prize in Biomedical Sciences

April 4, 2017

Prize bestowed for discovery of the mTOR pathway’s impact on age-related diseases

Researchers uncover a role for HSP90 in gene-environment interactions in humans

February 23, 2017

Researchers at Whitehead Institute have now uncovered a role for the protein-folding chaperone HSP90 in humans, not only as a modifier of the effects of mutations, but as a mediator of the impact of the environment on the function of mutant proteins. And these effects of HSP90 can alter the course of human diseases.

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