Tag: Protein Function

Illustration of scientist cutting a cell in half with a pizza cutter

To divide or not to divide?

August 15, 2019

Whitehead Institute team reveals molecular program that controls cells’ capacity for division

Collage of images in regeneration piece: Planarians, liver cells, and stem cells

The science of self-repair: regeneration research at Whitehead Institute

June 17, 2019

Researchers at Whitehead Institute are uncovering the underlying genetics, mechanisms, and principles of regeneration. 

Photo of Whitehead Institute Postdoc Izabella Pena

Whitehead Institute Postdoc Izabella Pena Selected as a 2019 Pew Latin American Fellow

June 10, 2019

Pena, who hails from Brazil, studies in Whitehead Institute Member David Sabatini's lab how cells calibrate their growth, metabolism, and proliferation based on nutrient availability 

Illustration of a mitochondrion

Drug-resistant cancer cells create own Achilles heel

May 27, 2019

Whitehead Institute and Broad Institute researchers determine that cancer cells commonly change their energy source, creating a weakness that the drug elesclomol exploits to resensitize cancer cells to proteasome inhibitors

Whitehead Institute Member Pulin Li

Pulin Li joins Whitehead Institute

April 2, 2019

Whitehead Institute announced today that the developmental and synthetic biologist Pulin Li will join the Institute in May as its newest Member. 

Immunofluorescence microscopy for meiotic markers in adult mouse testes

Start signal for sex cell creation

February 27, 2019

One protein is responsible for regulating a large network of genes that prompt cells to begin meiosis, the type of cell division that produces sex cells

Toxoplasma gondii (T. gondii) cells lose form and fail to replicate after degradation of GAPM proteins.

How one parasite stays in shape

January 23, 2019

Researchers in Whitehead Institute Member Sebastian Lourido’s lab identify the linchpin proteins of parasite Toxoplasma gondii’s cytoskeleton.

Pollen grains

A tough case cracked

December 17, 2018

The detailed molecular structure of the inert plant material sporopollenin — key for the emergence of land plants — has been resolved

Illustration of observatory focused on DNA constellation

Activating a new understanding of gene regulation

November 15, 2018

A previously mysterious part of transcription factors, the activation domain, plays a key role in forming phase separated "droplets" that concentrate proteins required for transcription near genes

Illustration of a hand assembling a brain jigsaw puzzle

Only in your head

October 9, 2018

Researchers uncover how a ubiquitously expressed mutation causes a brain-specific disorder.

Toxoplasma gondii parasites

Parasite’s riff on essential enzyme highlights unique biology

September 18, 2018

In the apicomplexan parasite Toxoplasma gondii (T. gondiiWhitehead Member Sebastian Lourido studies, he has identified key components of the ATP synthase which differ from that of humans. These differences underscore the unique biology of T. gondii and highlight the dissimilarities between them and their human hosts.    

Images of condensates and model of a condensate

Transcriptional droplets provide evidence for new model of gene control

June 21, 2018

Whitehead Institute scientists have found evidence that the apparatus that transcribes DNA into RNA is concentrated into specialized droplets, or “condensates”, at genes that control cell identity. 

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