Tag: Protein Function

Type 1 diabetes from a beta cell’s perspective

September 24, 2020

A new experimental system shows how insulin-producing beta cells react under autoimmune attack during type 1 diabetes; the results could lead to better treatments

Bridging research and medicine: Whitehead Institute’s physician-scientists

August 12, 2020

Whitehead Institute’s physician-scientists, researchers who also practice medicine, use their unusual position to act as conduits between lab and clinic.

Proteins — and labs — coming together to prevent Rett syndrome

July 22, 2020

New discoveries about the disruption of condensates in the neurodevelopmental disorder Rett syndrome provide insights into how cells compartmentalize chromosomes as well as new potential paths for therapies.

A split image shows healthy and diseased airway cilia side by side. The healthy cilia are well-defined, the diseased look a little shapeless and stuck together.

From bedside to bench, and back again

April 22, 2020

A mysterious case in the clinic led Whitehead Institute researchers to discover a new genetic lung condition

A Toxoplasma cyst isolated from a mouse brain. The cyst wall is stained green and the parasites are stained magenta.

Putting a finger on the switch of chronic parasite infection

January 16, 2020

Researchers at Whitehead Institute have discovered the master regulator necessary for the pervasive parasite Toxoplasma gondii to chronically infect its host. This finding provides important insights into the parasite’s biology and allows scientists in the laboratory to control if and when the parasite can differentiate into its chronic stage, which may inform research into prevention and treatment of infection.

Image of structure of the raptor - rag - ragulator protein comples

Whitehead Institute team resolves structure of master growth regulator

October 10, 2019

New paper in Science reveals how mTORC1 docks at lysosomal surface  


Illustration of scientist letting genie DNA out of a pot

Looking Beyond the Gene: An Introduction

September 30, 2019

Whitehead Institute researchers are uncovering new ways that genes are regulated that upend existing paradigms of gene expression and provide important insights into health and disease. This collection of stories and multimedia explores that research.

Illustration of a hairpin loop from a pre-mRNA

Regulatory RNA: The sculptors of gene expression

September 30, 2019

Whitehead Institute scientists have been uncovering the roles of regulatory RNA in controlling gene expression

Illustration of moths around a light

Signaling factor seeking gene

September 25, 2019

Whitehead Institute researchers have discovered that particular signaling pathways, which transmit environmental cues and effect changes in gene expression, rely on phase-separated condensates to find, occupy, and activate the right genes in each cell type

Illustration of scientist cutting a cell in half with a pizza cutter

To divide or not to divide?

August 15, 2019

Whitehead Institute team reveals molecular program that controls cells’ capacity for division

Collage of images in regeneration piece: Planarians, liver cells, and stem cells

The science of self-repair: regeneration research at Whitehead Institute

June 17, 2019

Researchers at Whitehead Institute are uncovering the underlying genetics, mechanisms, and principles of regeneration. 

Photo of Whitehead Institute Postdoc Izabella Pena

Whitehead Institute Postdoc Izabella Pena Selected as a 2019 Pew Latin American Fellow

June 10, 2019

Pena, who hails from Brazil, studies in Whitehead Institute Member David Sabatini's lab how cells calibrate their growth, metabolism, and proliferation based on nutrient availability 

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