Tag: Protein Function

Whitehead Institute Member Pulin Li

Pulin Li joins Whitehead Institute

April 2, 2019

Whitehead Institute announced today that the developmental and synthetic biologist Pulin Li will join the Institute in May as its newest Member. 

Immunofluorescence microscopy for meiotic markers in adult mouse testes

Start signal for sex cell creation

February 27, 2019

One protein is responsible for regulating a large network of genes that prompt cells to begin meiosis, the type of cell division that produces sex cells

Toxoplasma gondii (T. gondii) cells lose form and fail to replicate after degradation of GAPM proteins.

How one parasite stays in shape

January 23, 2019

Researchers in Whitehead Institute Member Sebastian Lourido’s lab identify the linchpin proteins of parasite Toxoplasma gondii’s cytoskeleton.

Pollen grains

A tough case cracked

December 17, 2018

The detailed molecular structure of the inert plant material sporopollenin — key for the emergence of land plants — has been resolved

Illustration of observatory focused on DNA constellation

Activating a new understanding of gene regulation

November 15, 2018

A previously mysterious part of transcription factors, the activation domain, plays a key role in forming phase separated "droplets" that concentrate proteins required for transcription near genes

Illustration of a hand assembling a brain jigsaw puzzle

Only in your head

October 9, 2018

Researchers uncover how a ubiquitously expressed mutation causes a brain-specific disorder.

Toxoplasma gondii parasites

Parasite’s riff on essential enzyme highlights unique biology

September 18, 2018

In the apicomplexan parasite Toxoplasma gondii (T. gondiiWhitehead Member Sebastian Lourido studies, he has identified key components of the ATP synthase which differ from that of humans. These differences underscore the unique biology of T. gondii and highlight the dissimilarities between them and their human hosts.    

Images of condensates and model of a condensate

Transcriptional droplets provide evidence for new model of gene control

June 21, 2018

Whitehead Institute scientists have found evidence that the apparatus that transcribes DNA into RNA is concentrated into specialized droplets, or “condensates”, at genes that control cell identity. 

Image of GATOR1 structure

Structure of key growth regulator revealed

March 28, 2018

Researchers solve molecular structure of GATOR1 complex using cryo-electron microscopy

Fluorescently-tagged IAPP oligomers can be seen trafficking through yeast cells

Toxic proteins and type 2 diabetes

March 8, 2018

New study in yeast implicates a molecular de-clogger in disease biology

Illustration of neighborhoods within DNA loops

New study prompts rethinking transcription factor’s role in control of gene expression

December 7, 2017

Like proteins, genomes must fold appropriately to function properly; some transcription factors provide the structural support

Image of a cell in anaphase

Of highways, engines, and chromosomes

November 16, 2017

Whitehead researchers unravel fundamental molecular machinery that propels chromosome movement

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