Tag: Protein Function

Illustration of observatory focused on DNA constellation

Activating a new understanding of gene regulation

November 15, 2018

A previously mysterious part of transcription factors, the activation domain, plays a key role in forming phase separated "droplets" that concentrate proteins required for transcription near genes

Illustration of a hand assembling a brain jigsaw puzzle

Only in your head

October 9, 2018

Researchers uncover how a ubiquitously expressed mutation causes a brain-specific disorder.

Toxoplasma gondii parasites

Parasite’s riff on essential enzyme highlights unique biology

September 18, 2018

In the apicomplexan parasite Toxoplasma gondii (T. gondiiWhitehead Member Sebastian Lourido studies, he has identified key components of the ATP synthase which differ from that of humans. These differences underscore the unique biology of T. gondii and highlight the dissimilarities between them and their human hosts.    

Images of condensates and model of a condensate

Transcriptional droplets provide evidence for new model of gene control

June 21, 2018

Whitehead Institute scientists have found evidence that the apparatus that transcribes DNA into RNA is concentrated into specialized droplets, or “condensates”, at genes that control cell identity. 

Image of GATOR1 structure

Structure of key growth regulator revealed

March 28, 2018

Researchers solve molecular structure of GATOR1 complex using cryo-electron microscopy

Fluorescently-tagged IAPP oligomers can be seen trafficking through yeast cells

Toxic proteins and type 2 diabetes

March 8, 2018

New study in yeast implicates a molecular de-clogger in disease biology

Illustration of neighborhoods within DNA loops

New study prompts rethinking transcription factor’s role in control of gene expression

December 7, 2017

Like proteins, genomes must fold appropriately to function properly; some transcription factors provide the structural support

Image of a cell in anaphase

Of highways, engines, and chromosomes

November 16, 2017

Whitehead researchers unravel fundamental molecular machinery that propels chromosome movement

Illustration of scientist opening a cell and looking at a molecule

Key nutrient sensor identified for cellular pathway linking nutrient availability to cell growth

November 9, 2017

Whitehead Member David Sabatini has identified the methionine sensor in the mTOR pathway, which is a crucial metabolic pathway in cells. His work provides interesting data suggesting that the anti-aging and anti-diabetes effects of low methionine and mTOR inhibition may be connected.

Image of red algae and Roland Kersten on Ventura beach

A new workflow for natural product characterization comes ashore with red algae

October 30, 2017

Whitehead Member Jing-Ke Weng uses an omics-based path for identifying and generating sesquiterpene-based therapeutics at scale.

Image of a breast cancer cell

Stuck on the membrane: A pro-metastatic transcription factor’s journey from anonymity to a promising target for breast cancer therapy

October 20, 2017

Whitehead Member Piyush Gupta has identified a protein stuck in the cell membrane that plays an important role in a cellular pathway crucial for cancer metastasis. The protein is a potential new target for breast cancer therapy that targets the cancer cells' metastatic behavior. 

Illustration of scientist measuring a cell on a scale

Study reveals key molecular link in major cell growth pathway

October 19, 2017

A team of scientists led by Whitehead Institute has uncovered a surprising molecular link that connects how cells regulate growth with how they sense and make available the nutrients required for growth.  The researchers’ findings also implicate a new protein, SLC38A9, as a potential drug target in pancreatic cancer. 

Pages

© Whitehead Institute for Biomedical Research              455 Main Street          Cambridge, MA 02142