Tag: Immune System

Schematic of microengraved slide use

Protein-printing technique gives snapshots of immune system defense

November 3, 2008

A new technique lets researchers, for the first time, look at single white blood cells and measure specific characteristics of the set of antibodies they produce when the body is under attack.

Schematic of reprogramming mouse cells

Mature B cells reprogrammed to stem-cell-like state

April 17, 2008

Fully differentiated cells can be reprogrammed to induced pluripotent stem (IPS) cells.

Schematic of neutrophil response

White blood cells are picky about sugar

July 11, 2007

Neutrophils recognize and respond to a particular form of sugar contained on the surface of pathogenic fungi.

Schematic showing the electron density of the herpes-specific protein m48

New drug target for herpes viruses?

March 8, 2007

Researchers have solved the complex structure of a recently discovered protein that is found in a wide range of herpes viruses.

New Whitehead Fellow Kate Rubins studies infectious disease

March 8, 2007

She investigates poxviruses, a class that includes not only smallpox but cowpox, monkeypox and vaccinia—the virus from which the smallpox vaccine is developed.

Schematic of identifying Foxp3 interacts with the genome

Cracking open the black box of autoimmune disease

January 21, 2007

Researchers have identified a key set of genes that lie at the core of autoimmune disease.

Diagram of protein being ejected from a cell

Virus yields clues into immune system

May 31, 2006

Ploegh lab discovers a key component in the machinery with which cells dispose of misfolded proteins.

Image of yeast cells, some of which have been "unmasked"

Cloaking device helps pathogens evade immune system

May 12, 2006

A network of genes might help pathogenic fungi hide.

Signals for war

November 16, 2005

Your immune system is an army on full alert. How does it recognize the enemy when it's under attack?

Drug hunters

September 22, 2004

Ask Microbia CEO Peter Hecht if drug discovery is an art or science, and he’ll likely tell you that it’s both. Reflecting on the company’s short—yet remarkably productive—history, the former Whitehead postdoc is quick to attribute Microbia’s success to a convergence of science, people, and passion.

New Compound Library to Speed Drug Discovery

September 4, 2003

Making drugs is a difficult and costly business. Even before companies spend exorbitant amounts on clinical trials (most of which fail), they already have spent significant time and money identifying the best drug candidates for those trials. Brent Stockwell has developed a possible shortcut for this early drug-development stage.

Studies Shed Light on Gene Response to Bacterial Infections

July 24, 2003

Making a medical diagnosis today often relies on symptomology, bacterial cultures, stain tests, experience – and luck. But new research by systems biologists at Whitehead aims to offer physicians new diagnostic tools by uncovering important differences in the way immune cells respond to bacteria.

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