Tag: Immune System

Novel method could improve the performance of proteins used therapeutically

March 9, 2011

Whitehead Institute scientists have created a method that uses the enzyme sortase A to site-specifically modify proteins. Using this technique, researchers were able to increase potency, slow the metabolism, and improve thermal stability of several proteins.

New model tracks the immune response to a T

April 8, 2010

Using T cells primed for the infectious disease toxoplasmosis, Whitehead Institute researchers have created novel mouse models of the immune system that more accurately reflect how immune cells actually respond to pathogens in their presence.

Schematic of YOD1's role

Jamming cell’s protein disposal shows how system works

October 26, 2009

Whitehead Institute scientists have determined that a protein known as YOD1 plays a critical role in the disposal of misfolded cellular proteins. The researchers identified YOD1’s role by blocking its function, a manipulation that halts the elimination of errant proteins entirely. The finding should help bring greater understanding to this vital but complex cellular process.

Photos of healthy greater wax moths and those killed by fungus

The Hsp90-antifungal combo, please: Compromising fungi in the immunocompromised

February 9, 2009

Even the most drug-resistant fungi can be eradicated in multiple in vitro and in vivo models using a lethal combination of an antifungal agent and inhibition of a specific heat shock protein (Hsp90). Such findings could point to a novel approach for the development of future antifungal therapies for patients with compromised immune systems, including HIV, chemotherapy, and organ transfer patients.

Scientists pinpoint immune system targets in complex pathogens

December 5, 2008

Scientists have long struggled for details on how the immune system responds to complex pathogens such as the parasite Toxoplasma gondii and herpes viruses. Adapting an existing technology, researchers have pinpointed precise molecular targets that these pathogens present to signal T cells.

Schematic of microengraved slide use

Protein-printing technique gives snapshots of immune system defense

November 3, 2008

A new technique lets researchers, for the first time, look at single white blood cells and measure specific characteristics of the set of antibodies they produce when the body is under attack.

Schematic of reprogramming mouse cells

Mature B cells reprogrammed to stem-cell-like state

April 17, 2008

Fully differentiated cells can be reprogrammed to induced pluripotent stem (IPS) cells.

Schematic of neutrophil response

White blood cells are picky about sugar

July 11, 2007

Neutrophils recognize and respond to a particular form of sugar contained on the surface of pathogenic fungi.

Schematic showing the electron density of the herpes-specific protein m48

New drug target for herpes viruses?

March 8, 2007

Researchers have solved the complex structure of a recently discovered protein that is found in a wide range of herpes viruses.

New Whitehead Fellow Kate Rubins studies infectious disease

March 8, 2007

She investigates poxviruses, a class that includes not only smallpox but cowpox, monkeypox and vaccinia—the virus from which the smallpox vaccine is developed.

Schematic of identifying Foxp3 interacts with the genome

Cracking open the black box of autoimmune disease

January 21, 2007

Researchers have identified a key set of genes that lie at the core of autoimmune disease.

Diagram of protein being ejected from a cell

Virus yields clues into immune system

May 31, 2006

Ploegh lab discovers a key component in the machinery with which cells dispose of misfolded proteins.

Pages

© Whitehead Institute for Biomedical Research              455 Main Street          Cambridge, MA 02142