Tag: Bartel Lab

Collage of various pets of people at Whitehead Institute

Beyond the Lab Bench: A Look at the Traditions That Make Whitehead Institute Unique

December 10, 2019

The Caf: A Kendall Square Institution

Two halves of a puzzle being fitted together

The surprising individuality of microRNAs

December 5, 2019

Whitehead Institute researchers advance the predictive model for the influence of microRNAs on gene expression in a cell. Their findings illustrate that high-, medium-, and low-affinity microRNA target sites unexpectedly vary between different microRNAs, and that in some cases they include imperfectly matched sequences.

Illustration of scientist letting genie DNA out of a pot

Looking Beyond the Gene: An Introduction

September 30, 2019

Whitehead Institute researchers are uncovering new ways that genes are regulated that upend existing paradigms of gene expression and provide important insights into health and disease. This collection of stories and multimedia explores that research.

Illustration of a hairpin loop from a pre-mRNA

Regulatory RNA: The sculptors of gene expression

September 30, 2019

Whitehead Institute scientists have been uncovering the roles of regulatory RNA in controlling gene expression

Illustration of scientist and trees

A Fruitful Pursuit: Plant Biology at Whitehead Institute

January 24, 2019

Decades of pioneering plant research at Whitehead Institute have led to biological insights and useful discoveries

Illustration of person pulling down a segment of DNA

Revising the textbook on introns

January 16, 2019

Whitehead Institute researchers uncover a group of introns in yeast with surprising stability and function

Postdoc Jarrett Smith

Jarrett Smith receives Hanna Gray Fellowship from HHMI

September 12, 2018

Whitehead Institute postdoc receives Hannah Gray Fellowship from Howard Hughes Medical Institute

Illustration of a brain containing RNAs

Network of diverse noncoding RNAs acts in the brain

June 7, 2018

First known network consisting of three types of regulatory RNAs is identified

Image of fish and RNA hairpins

Pairing mismatch helps impaired fish RNA cleavage proceed swimmingly

December 21, 2017

Researchers at Whitehead Institute have uncovered how small changes in the fish Argonaute (Ago) protein, an RNA slicing protein, that happened in its lineage an estimated 300 million years ago greatly diminished the efficiency of RNAi in these animals, while another ancestral feature, in a critical pre-microRNA, was retained that enabled the microRNA to still be produced despite the fish’s impaired Ago protein.

Diagram of  high-throughput sequencing-based method that measures the poly(A) tails of individual messenger RNA molecules

A protein-production tale of the tape: separating poly(A)-tail length from translational efficiency

January 29, 2014

Whitehead Institute researchers have determined that poly(A) tails on messenger RNAs (mRNAs) shift their role in the regulation of protein production during early embryogenesis. This finding about the regulation of mRNA translation also provides insight into how microRNAs control protein production. 

Model of eukaryotic argonaute protein

Structure of RNAi complex now crystal clear

June 20, 2012

Researchers at Whitehead Institute and Memorial Sloan-Kettering Cancer Center have defined and analyzed the crystal structure of a yeast Argonaute protein bound to RNA.

Photos of zebrafish heads, one with reduced lincRNA megamind production and an enlarged head, and the other normal megamind production and head size

Long intervening non-coding RNAs play pivotal roles in brain development

December 22, 2011

Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during brain development in zebrafish, and went on to show that the human versions of these RNAs can substitute for the zebrafish lincRNAs.

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