Tag: Bartel Lab

Image of fish and RNA hairpins

Pairing mismatch helps impaired fish RNA cleavage proceed swimmingly

December 21, 2017

Researchers at Whitehead Institute have uncovered how small changes in the fish Argonaute (Ago) protein, an RNA slicing protein, that happened in its lineage an estimated 300 million years ago greatly diminished the efficiency of RNAi in these animals, while another ancestral feature, in a critical pre-microRNA, was retained that enabled the microRNA to still be produced despite the fish’s impaired Ago protein.

Diagram of  high-throughput sequencing-based method that measures the poly(A) tails of individual messenger RNA molecules

A protein-production tale of the tape: separating poly(A)-tail length from translational efficiency

January 29, 2014

Whitehead Institute researchers have determined that poly(A) tails on messenger RNAs (mRNAs) shift their role in the regulation of protein production during early embryogenesis. This finding about the regulation of mRNA translation also provides insight into how microRNAs control protein production. 

Model of eukaryotic argonaute protein

Structure of RNAi complex now crystal clear

June 20, 2012

Researchers at Whitehead Institute and Memorial Sloan-Kettering Cancer Center have defined and analyzed the crystal structure of a yeast Argonaute protein bound to RNA.

Photos of zebrafish heads, one with reduced lincRNA megamind production and an enlarged head, and the other normal megamind production and head size

Long intervening non-coding RNAs play pivotal roles in brain development

December 22, 2011

Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during brain development in zebrafish, and went on to show that the human versions of these RNAs can substitute for the zebrafish lincRNAs.

RNA snippets control protein production by disabling mRNAs

August 16, 2010

Short pieces of RNA, called microRNAs, control protein production by causing the proteins’ RNA templates (known as messenger RNA or mRNA) to be disabled by the cell, according to Whitehead Institute scientists.

RNA interference found in budding yeasts

September 10, 2009

Some budding yeast species have the ability to silence genes using RNA interference (RNAi). Until now, most researchers thought that no budding yeasts possess the RNAi pathway because Saccharomyces cerevisiae, the protoypical model budding yeast does not.

The ends of mRNAs may prevent the beginnings of cancer

August 20, 2009

The tail ends of cellular protein templates, regions often thought relatively inconsequential, may actually play a role in preventing normal cells from becoming cancerous.

Short RNAs show a long history

October 1, 2008

MicroRNAs and piRNAs, two classes of small RNAs that regulate genes, have been discovered within diverse animal lineages, implying that they have been present since the ancestor of all animals (about a billion years ago).

How short RNAs influence many proteins

July 30, 2008

The first large-scale study of the protein output of genes targeted by microRNAs confirms that each microRNA adjusts the production of many proteins, and sheds important light on how this regulation occurs.

MicroRNA convicted of triggering metastasis

September 26, 2007

Overabundance of a single microRNA can cause tumors to spread to distant tissues in mice.

MicroRNA helps prevent tumors

February 22, 2007

A microRNA directly regulates a gene implicated in human cancers.

Scientists discover new class of RNAs

January 10, 2007

Their uniform structure strongly indicates an important biological role.

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