Research

Research at Whitehead

Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 16 faculty Members and 2 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.

Members

 

Fellows

Research News

April 23, 2014

From liability to viability: Genes on the Y chromosome prove essential for male survival

The human Y chromosome has over the course of millions of years of evolution managed to preserve a small set of genes that has ensured not only its own survival but also the survival of men. Moreover, the vast majority of these tenacious genes appear to have little if any role in sex determination or sperm production. Taken together, these remarkable finding suggest that because these Y-linked genes are active across the body, they may actually be contributing to differences in disease susceptibility and severity observed between men and women.

Schematic of how interrupting ATPIF1 rescues cells with mitochondrial dysfunction

March 27, 2014

Scientists find potential target for treating mitochondrial disorders

Mitochondria, long known as “cellular power plants” for their generation of the key energy source adenosine triphosphate (ATP), are essential for proper cellular functions. Mitochondrial defects are often observed in a variety of diseases, including cancer, Alzheimer’s disease, and Parkinson’s disease, and are the hallmarks of a number of untreatable genetic mitochondrial disorders whose manifestations range from muscle weakness to organ failure. Whitehead Institute scientists have identified a protein whose inhibition could hold the key to alleviating suffering caused by such disorders.

Whitehead Institute and Biogen Idec logos

March 25, 2014

Whitehead Institute and Biogen Idec Initiate Discovery Research Collaboration

Whitehead Institute today announced it has entered into a scientific research collaboration with Biogen Idec aimed at driving early stage research that may lead to the development of novel therapies across a broad range of disease areas.

Diagram of the Nutrostat machine

March 16, 2014

How diabetes drugs may work against cancer

Scientists at Whitehead Institute have pinpointed a major mitochondrial pathway that imbues cancer cells with the ability to survive in low-glucose environments. By identifying cancer cells with defects in this pathway or with impaired glucose utilization, the scientists can predict which tumors will be sensitive to these anti-diabetic drugs known to inhibit this pathway.

Recent papers

March 27, 2014

Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib.

Cancer Discov. 2014 Mar 27.


March 25, 2014

Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.

J Med Chem. 2014 Mar 25.


March 23, 2014

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Nat Methods. 2014 Mar 23.


All research papers

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