Research at Whitehead
Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 16 faculty Members and 2 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.
April 20, 2015
Imaging immunity: Noninvasive imaging of immune system detects tumors, could monitor therapeutic response
A novel approach that allows real-time imaging of the immune system’s response to the presence of tumors—without the need for blood draws or invasive biopsies—offers a potential breakthrough both in diagnostics and in the ability to monitor efficacy of cancer therapies.
April 8, 2015
Biologists at Whitehead Institute and MIT have discovered a vulnerability of brain cancer cells that could be exploited to develop more-effective drugs against brain tumors.
April 3, 2015
Candida albicans is a human pathogen that causes potentially lethal infections in immunocompromised individuals. Efforts to overcome Candida’s innate resistance to many drugs have been thwarted by an absence of tools enabling genetic modifications. Now, using a modified CRISPR-Cas system, Whitehead Institute researchers can edit the fungus’s genome systematically—an approach that could help scientists understand Candida’s unique biology and identify potential drug targets.
April 2, 2015
A team of Whitehead Institute scientists has discovered that during division, stem cells distinguish between old and young mitochondria and allocate them disproportionately between daughter cells.
March 26, 2015
Nutrient-sensing mechanisms across evolution.
Cell. 2015 Mar 26;161(1):67-83.
March 24, 2015
Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions.
Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3841-6.
March, 23, 2015
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.
Nat Biotechnol. 2015 Mar 23.