Research

Research at Whitehead

Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 16 faculty Members and 2 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.

Members

 

Fellows

Research News

Image of brain samples showing gene activity in ischemic areas

April 8, 2015

Biologists identify brain tumor weakness

Biologists at Whitehead Institute and MIT have discovered a vulnerability of brain cancer cells that could be exploited to develop more-effective drugs against brain tumors.

Image of red and white yeast colonies

April 3, 2015

CRISPR-Cas genome editing of Candida albicans holds promise for overcoming deadly fungal infections

Candida albicans is a human pathogen that causes potentially lethal infections in immunocompromised individuals. Efforts to overcome Candida’s innate resistance to many drugs have been thwarted by an absence of tools enabling genetic modifications. Now, using a modified CRISPR-Cas system, Whitehead Institute researchers can edit the fungus’s genome systematically—an approach that could help scientists understand Candida’s unique biology and identify potential drug targets.

Dividing human mammary stem cells

April 2, 2015

Age discrimination during cell division maintains the ‘stem’ in stem cells

A team of Whitehead Institute scientists has discovered that during division, stem cells distinguish between old and young mitochondria and allocate them disproportionately between daughter cells.

Diagram of how Scr7 improves CRISPR/Cas

March 23, 2015

Refined CRISPR/Cas genome editing accelerates generation of transgenic mice

Although the genome editing system known as CRISPR/Cas has revolutionized genetic research in cell lines, its overall efficiency has been relatively poor when used to generate genetically altered animals for disease modeling.  Now Whitehead Institute scientists have altered the approach in a manner that could accelerate the production of mice carrying precise mutations of multiple genes.

Recent papers

March 26, 2015

Nutrient-sensing mechanisms across evolution.

Cell. 2015 Mar 26;161(1):67-83.


March 24, 2015

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3841-6.


March, 23, 2015

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

Nat Biotechnol. 2015 Mar 23.


All research papers

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