Research

Research at Whitehead

Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 17 faculty Members and 2 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.

Members

 

Fellows

Research News

Photo of chimera mouse with dark hairs

January 25, 2016

New mouse-human modeling system enables study of disease development in vivo

Whitehead Institute researchers have created a new mouse-human modeling system that could be used to study neural crest development as well as the modeling of a variety of neural crest related diseases, including such cancers as melanoma and neurofibromatosis. 

Diagram showing the frequency of mutations in the gene for RagC

December 21, 2015

Scientists identify mTOR pathway mutations in follicular lymphoma

A team of researchers from Whitehead Institute and Queen Mary University of London (QMUL) have identified in follicular lymphoma tumors a mutated protein that could serve as a biomarker to predict therapeutic response.

Model for the architecture of the CCAN

November 19, 2015

Architecture of protein complex hints at its foundational function in chromosome segregation

The Constitutive Centromere-Associated Network (CCAN) plays a foundational role in the machine that directs chromosome segregation during cell division. On the left is a model of the complete machine (the kinetochore) attached to the microtubule that provides the power for chromosome segregation. The right side depicts the direct interactions between CCAN sub-complexes based on Whitehead scientists’ research as viewed from above the CENP-A nucleosome, either occuring on a single nucleosome (top) or or between two nucleosomes (bottom).”

Diagram of the crystal structure of Cas9 in complex with guide RNA and its target DNA.

October 15, 2015

Screen of human genome reveals set of genes essential for cellular viability

Using two complementary analytical approaches, scientists at Whitehead Institute and Broad Institute of MIT and Harvard have for the first time identified the universe of genes in the human genome essential for the survival and proliferation of human cell lines or cultured human cells. Their findings and the materials they developed in conducting the research will not only serve as invaluable resources for the global research community but should also have application in the discovery of drug-targetable genetic vulnerabilities in a variety of human cancers.

Recent papers

November 25, 2015

The molecular basis for centromere identity and function.

Nat Rev Mol Cell Biol. 2015 Nov 25.


November 24, 2015

Combined loss of Tet1 and Tet2 promotes B cell, but not myeloid malignancies, in mice.

Cell Rep. 2015 Nov 24;13(8):1692-704.


November 23, 2015

Tet1 and Tet2 protect DNA methylation canyons against hypermethylation.

Mol Cell Biol. 2015 Nov 23.


All research papers

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