Research

Research at Whitehead

Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 16 faculty Members and 2 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.

Members

 

Fellows

Research News

June 4, 2015

Forks colliding: How DNA breaks during re-replication

Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of such genomic damage. Moreover, because errors arising during DNA replication and gene amplification result in chromosomal abnormalities often found in malignant cells, these new findings may bolster our understandings of certain drivers of cancer progression.

Image of human red blood cells

May 11, 2015

Repurposed anti-cholesterol drug could improve treatment-resistant anemias

Using a mouse model, the lab of Whitehead Institute Founding Member Harvey Lodish, has now determined that combining the cholesterol-lowering drug fenofibrate with glucocorticoids could allow for dramatically lower steroid doses in the treatment of  Diamond Blackfan anemia and other erythropoietin-resistant anemias.

Image of cells with and without RUNX1 turned on

May 6, 2015

Scientists identify gene required for differentiation of breast stem cells

Scientists have applied a new method of analyzing cell states to identify a gene required for breast stem cells to differentiate. This gene, RUNX1, is deregulated or mutated in some leukemias and breast cancers. The novel approach, known as PEACS, could also be used to screen for drugs that activate or inhibit the expression regulators of stem cell differentiation.

Image showing tumors

April 20, 2015

Imaging immunity: Noninvasive imaging of immune system detects tumors, could monitor therapeutic response

A novel approach that allows real-time imaging of the immune system’s response to the presence of tumors—without the need for blood draws or invasive biopsies—offers a potential breakthrough both in diagnostics and in the ability to monitor efficacy of cancer therapies.

Recent papers

March 26, 2015

Nutrient-sensing mechanisms across evolution.

Cell. 2015 Mar 26;161(1):67-83.


March 24, 2015

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3841-6.


March, 23, 2015

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

Nat Biotechnol. 2015 Mar 23.


All research papers

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