Research

Research at Whitehead

Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 17 faculty Members and 4 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.

Members

 

Fellows

Research News

Design of red blood cell capable of carrying antigenic peptides

March 6, 2017

Cargo-carrying red blood cells alleviate autoimmune diseases in mice

Using red blood cells modified to carry disease-specific antigens, a team of scientists from Whitehead Institute and Boston Children’s Hospital have prevented and alleviated two autoimmune diseases—multiple sclerosis (MS) and type 1 diabetes—in early stage mouse models.  This research is an exciting step toward therapeutics for autoimmune diseases, which affect an estimated 23 million Americans.

February 23, 2017

Researchers uncover a role for HSP90 in gene-environment interactions in humans

Researchers at Whitehead Institute have now uncovered a role for the protein-folding chaperone HSP90 in humans, not only as a modifier of the effects of mutations, but as a mediator of the impact of the environment on the function of mutant proteins. And these effects of HSP90 can alter the course of human diseases.

February 2, 2017

Researchers chart global genetic interaction networks in human cancer cells

Investigators at Whitehead Institute and the Broad Institute have succeeded in identifying the set of essential genes—those required for cellular proliferation and survival—in each of 14 human acute myeloid leukemia (AML) cell lines that had previously been characterized by genome sequencing. By combining their “gene essentiality map” with the existing genomic information, their study revealed liabilities in genetically defined subset of cancers that could be exploited for new therapies.

January 25, 2017

New Clues on the Basis of Parkinson’s Disease and Other “Synucleinopathies”

Parkinson’s disease (PD) and other “synucleinopathies” are known to be linked to the misfolding of alpha-synuclein protein in neurons. Less clear is how this misfolding relates to the growing number of genes implicated in PD through analysis of human genetics. Two new studies from researchers affiliated with Whitehead Institute and Massachusetts Institute of Technology explain how they used a suite of novel biological and computational methods to shed light on the question.

Recent papers

August 29, 2016

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.

Nat Chem Biol. 2016 Aug 29.


August 25, 2016

Cell-type-specific alternative splicing governs cell fate in the developing cerebral cortex.

Cell. 2016 Aug 25;166(5):1147-1162.e15.


August 25, 2016

Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism. 

Cell. 2016 Aug 25;166(5):1324-1337.e11.


All research papers

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