Research

Research at Whitehead

Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 16 faculty Members and 2 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.

Members

 

Fellows

Research News

Slides of tagged cells

September 2, 2015

Cellular recycling complexes may hold key to chemotherapy resistance

Upsetting the balance between protein synthesis, misfolding, and degradation drives cancer and neurodegeneration. Recent cancer treatments take advantage of this knowledge with a class of drugs that block protein degradation, known as proteasome inhibitors. Widespread resistance to these drugs limits their success, but Whitehead researchers have discovered a potential Achilles heel in resistance. With such understandings researchers may be able to target malignancy broadly, and more effectively.

Diagram of CDPK1 in its active and inactive forms

August 24, 2015

Tiny antibodies point to vulnerability in disease-causing parasites

By teasing apart the structure of an enzyme vital to the parasites that cause toxoplasmosis and malaria, Whitehead Institute scientists have identified a potentially ‘drugable’ target that could prevent parasites from entering and exiting host cells.

Electron microscope image of a mitochondrion

July 31, 2015

Amino acid shortage curbs proliferation in cells with mitochondrial dysfunction

According to Whitehead Institute researchers, cells with malfunctioning mitochondria are unable to proliferate due to a shortage of the amino acid aspartate, not because of an energy crisis, as was once thought. Mitochondrial dysfunction plays a role in a host of relatively rare disorders as well as neurodegenerative disorders, including Parkinson’s disease.

June 4, 2015

Forks colliding: How DNA breaks during re-replication

Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of such genomic damage. Moreover, because errors arising during DNA replication and gene amplification result in chromosomal abnormalities often found in malignant cells, these new findings may bolster our understandings of certain drivers of cancer progression.

Recent papers

March 26, 2015

Nutrient-sensing mechanisms across evolution.

Cell. 2015 Mar 26;161(1):67-83.


March 24, 2015

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3841-6.


March, 23, 2015

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

Nat Biotechnol. 2015 Mar 23.


All research papers

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