Research

Research at Whitehead

Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 16 faculty Members and 2 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.

Members

 

Fellows

Research News

Diagram of pseudouridylation of mRNA

September 15, 2014

Scientists discover RNA modifications in some unexpected places

Deploying sophisticated high-throughput sequencing technology, dubbed ψ-seq, a team of Whitehead Institute and Broad Institute researchers collaborated on a comprehensive, high-resolution mapping of ψ sites that confirms pseudouridylation, the most common post-transcriptional modification, does indeed occur naturally in mRNA.

Diagram of reprogramming factors in SNEL

September 4, 2014

New reprogramming factor cocktail produces therapy-grade induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) may hold the potential to cure damaged nerves, regrow limbs and organs, and perfectly model a patient’s particular disease. Yet these cells can acquire serious genetic and epigenetic abnormalities that lower the cells’ quality and limit their therapeutic usefulness. Now Whitehead Institute researchers have identified a cocktail of reprogramming factors that produces very high quality iPSCs.

Images of tissue sections from breast cancer patient biopsies

July 31, 2014

Master heat-shock factor supports reprogramming of normal cells to enable tumor growth and metastasis

Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat-Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis.

Image of iPipet

July 30, 2014

Innovative scientists update old-school pipetting with new-age technology

A team of Whitehead Institute researchers is bringing new levels of efficiency and accuracy to one of the most essential albeit tedious tasks of bench science: pipetting.

Recent papers

August, 2014

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering.

Nat Protoc. 2014 Aug;9(8):1956-68.


July 30, 2014

iPipet: sample handling using a tablet.

Nat Methods. 2014 Jul 30;11(8):784-785.


July 25, 2014

Depletion of RICTOR, an essential protein component of mTORC2, decreases male lifespan.

Aging Cell. 2014 Jul 25.


All research papers

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