Research

Research at Whitehead

Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 17 faculty Members and 4 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.

Members

 

Fellows

Research News

April 6, 2017

Growth medium based on human plasma rewires cell metabolism

Cultured human cells are the foundation for disease and drug research. Now Whitehead Institute researchers have designed a growth medium that more closely resembles the cells’ environment in the body—and demonstrated that, relative to decades-old recipes that have remained the workhorses of cell culture studies, it significantly alters the cells’ inner workings.

Image of an invasive outgrowth of cancer cells

April 3, 2017

Biomarker identified for likely aggressive, early stage breast cancer

Whitehead Institute scientists have identified a gene that could help clinicians discern which patients have aggressive forms of early stage breast cancer, which could prevent hundreds of thousands of women from undergoing unnecessary treatment and save millions of dollars.

Design of red blood cell capable of carrying antigenic peptides

March 6, 2017

Cargo-carrying red blood cells alleviate autoimmune diseases in mice

Using red blood cells modified to carry disease-specific antigens, a team of scientists from Whitehead Institute and Boston Children’s Hospital have prevented and alleviated two autoimmune diseases—multiple sclerosis (MS) and type 1 diabetes—in early stage mouse models.  This research is an exciting step toward therapeutics for autoimmune diseases, which affect an estimated 23 million Americans.

February 23, 2017

Researchers uncover a role for HSP90 in gene-environment interactions in humans

Researchers at Whitehead Institute have now uncovered a role for the protein-folding chaperone HSP90 in humans, not only as a modifier of the effects of mutations, but as a mediator of the impact of the environment on the function of mutant proteins. And these effects of HSP90 can alter the course of human diseases.

Recent papers

May 12, 2017

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

Nat Protoc. 2017 May;12(5):865-880.


April 6, 2017

mTOR signaling in growth, metabolism, and disease. 

Cell. 2017 Apr 6;169(2):361-371.


April 4, 2017

Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register. 

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3642-3647 


All research papers

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