Research at Whitehead
Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 16 faculty Members and 2 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.
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Fellows |
Research News
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June 9, 2013 Scientists identify potential drug target for treatment-resistant anemiasResearchers at Whitehead Institute have identified a key target protein of glucocorticoids, the drugs that are used to increase red blood cell production in patients with certain types of anemia, including those resulting from trauma, sepsis, malaria, kidney dialysis, and chemotherapy. |
May 30, 2013 Protein complex in key cell-growth pathway could help predict response to cancer therapyWhitehead Institute researchers have identified a protein complex that, when mutated, sends the master growth regulatory pathway known as mTORC1 into overdrive. Researchers believe that mutations in this complex could serve as biomarkers to predict response to rapamycin treatment in cancer patients. |
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May 2, 2013 Scientists revolutionize the creation of genetically altered mice to model human diseaseUsing a bacteria-based technique, Whitehead Institute Founding Member Rudolf Jaenisch has efficiently created mouse models with multiple gene mutations in a matter of weeks. |
April 11, 2013 Genetic master controls expose cancers’ Achilles’ heelIn a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed “super-enhancers” that control cell state and identity. |
Recent papers
june 1, 2013
Mechanisms and models of somatic cell reprogramming.
Nat Rev Genet. 2013 Jun;14(6):427-39.
May 31, 2013
A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Science. 2013 May 31;340(6136):1100-6.
May 29, 2013
Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways.
Proc Natl Acad Sci U S A. 2013 May 29.