Research at Whitehead

Whitehead Institute provides researchers with the resources and freedom to follow their scientific instincts, form novel collaborations, and conduct high-risk research. While probing basic biological processes, the Institute’s 16 faculty Members and 2 Fellows develop innovative technologies and lay the foundation for projects that improve human health. They run pioneering programs in cancer, immunology, developmental biology, stem cell science, regenerative medicine, genetics, and genomics.




Research News

September 24, 2015

New methodology tracks changes in DNA methylation in real time at single-cell resolution

Whitehead Institute researchers have developed a tool that allows scientists to monitor changes in DNA methylation over time in individual cells. Certain diseases, including cancer, cause changes in DNA methylation patterns, and the ability to document these alterations could aid in the development of novel therapies.

Diagram of RAB35's role in oncogenesis

September 3, 2015

New role for an old protein: Cancer causer

A protein known to play a role in transporting the molecular contents of normal cells into and out of various intracellular compartments can also turn such cells cancerous by stimulating a key growth-control pathway.

Diagram of cancer versus normal stem cells

September 3, 2015

Variations in cell programs control cancer and normal stem cells

In the breast, cancer stem cells and normal stem cells can arise from different cell types and tap into distinct yet related stem cell programs, according to Whitehead Institute researchers. The differences between these stem cell programs may be significant enough to be exploited by future therapeutics.

Slides of tagged cells

September 2, 2015

Cellular recycling complexes may hold key to chemotherapy resistance

Upsetting the balance between protein synthesis, misfolding, and degradation drives cancer and neurodegeneration. Recent cancer treatments take advantage of this knowledge with a class of drugs that block protein degradation, known as proteasome inhibitors. Widespread resistance to these drugs limits their success, but Whitehead researchers have discovered a potential Achilles heel in resistance. With such understandings researchers may be able to target malignancy broadly, and more effectively.

Recent papers

October 1, 2015

Efficient reprogramming of human fibroblasts and blood-derived endothelial progenitor cells using non-modified RNA for reprogramming and immune evasion.

Hum Gene Ther. 2015 Oct 1.

September 24, 2015

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Cell. 2015 Sep 24;163(1):174-86.

September 24, 2015

Tracing dynamic changes of DNA methylation at single-cell resolution.

Cell. 2015 Sep 24;163(1):218-29.

All research papers

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