Tag: Stem Cells + Therapeutic Cloning

Schematic of reprogramming mouse cells

Reprogrammed adult cells treat sickle-cell anemia in mice

December 6, 2007

This is the first proof of principle for using adult cells reprogrammed to an embryonic-stem-cell-like state, combined with gene and cell therapy, for successful disease treatment in mice.

Photo of two-headed worm

Heads or tails? Scientists identify gene that regulates polarity in regenerating flatworms

December 6, 2007

Inhibiting one gene resulted in animals making a head instead of a tail at the site of the wound.

Images showing the effects of Oct4

Adult stem cells lack key pluripotency regulator

October 10, 2007

The protein Oct4, which helps to maintain embryonic stem cells, has been shown to be virtually absent in adult stem cells.

Green fluorescent mesenchymal stem cells in a primary tumor

Cancer cells enlist adult stem cells to promote metastasis

October 3, 2007

The conscripts secrete a protein that fosters cell movement and invasion.

Scientists identify embryonic stem cells by appearance alone

August 27, 2007

Scientist can now identify pluripotent stem cells based solely on their physical appearance.

Normal cells transformed into cancerous ones

Newly created cancer stem cells could aid breast cancer research

August 13, 2007

After being injected with just 100 cells, mice develop tumors that metastasize.

Whitehead postdoctoral researchers Stuart Levine and Matthew Guenther

Cells take risks with their identities

July 12, 2007

Contrary to textbook models, many genes that should be “off” in embryonic stem cells and specialized adult cells remain primed to produce master regulatory proteins, leaving those cells vulnerable to identity changes.

Reprogrammed fibroblasts identical to embryonic stem cells

June 6, 2007

Researchers have manipulated mouse fibroblasts and turned them into cells with such developmental elasticity that they appear identical to embryonic stem cells.

Mapping the foundation of human development

April 20, 2006

Researchers have determined how a key developmental ingredient controls the genome.

Mad-cow culprit maintains stem cells

January 30, 2006

The same protein that causes neurodegenerative conditions such as bovine spongiform encephalopathy (mad cow disease) is also important for helping certain adult stem cells maintain themselves.

Powerful technique for multiplying adult stem cells may aid therapies

January 23, 2006

Researchers have discovered a way to multiply an adult stem cell 30-fold, an expansion that offers tremendous promise for treatments such as bone marrow transplants and perhaps even gene therapy.

Cloned stem cells prove identical to fertilized stem cells

January 17, 2006

Researchers analyzed the complete gene-expression profiles of both cloned and fertilization-derived stem cells in mice and concluded that the two are indistinguishable.

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