Tag: Stem Cells + Therapeutic Cloning

Protein that predicts prognosis of leukemia patients may also be a therapeutic target

July 8, 2010

Researchers at Whitehead Institute and Children’s Hospital Boston have identified a protein, called Musashi 2, that is predictive of prognosis in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) patients. High levels of Musashi 2 protein is associated with increased cell proliferation, decreased cell maturation, and multiple cancer-related cellular pathways in human leukemias.

Image of purple intestinal epithelial cells extracted from a teratoma seeded by reprogrammed blood cells.

Reprogrammed human blood cells show promise for disease research

July 1, 2010

Cells from frozen human blood samples can be reprogrammed to an embryonic stem-cell-like state, according to Whitehead Institute researchers. These cells can be multiplied and used to study the genetic and molecular mechanisms of blood disorders and other diseases.

Low oxygen levels prevent X chromosome inactivation in human embryonic stem cells

May 13, 2010

Oxygen levels in the lab can permanently alter human embryonic stem (ES) cells, specifically inducing X chromosome inactivation in female cells, according to Whitehead Institute researchers.

Scientists create human embryonic stem cells with enhanced pluripotency

May 3, 2010

Whitehead Institute researchers have converted established human induced pluripotent stem (iPS) cells and human embryonic stem (ES) cells to a base state of greater pluripotency. 

Embryonic stem cells reveal oncogene’s secret growth formula

April 29, 2010

Whitehead Institute researchers have identified the mechanism that the protein c-Myc uses to regulate gene transcription, which affects one-third of the expressed genes in the genome. The work also reveals a general role for this mechanism in gene control, which is called transcriptional pause release.

Image showing wntP-1 concentration at planarian wound site

Figuring out the heads or tails decision in regeneration

September 14, 2009

Wounds trigger regeneration in planaria, a flatworm commonly studied for its regenerative capabilities. Until now, no molecular connection between wounding and the onset of the regeneration of an entire head or tail in planaria had been identified.

Technique enables efficient gene targeting in human embryonic stem cells

August 13, 2009

A novel technique allows researchers to efficiently and precisely modify or introduce genes into the genomes of human embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells, according to Whitehead scientists.

Breakthrough method produces Parkinson’s disease patient-specific stem cells free of harmful reprogramming genes

March 5, 2009

Deploying a method that removes potentially cancer-causing genes, Whitehead Institute researchers have “reprogrammed” human skin cells from Parkinson’s disease patients into an embryonic-stem-cell-like state. Whitehead scientists then used these so-called induced pluripotent stem (iPS) cells to create dopamine-producing neurons, the cell type that degenerates in Parkinson’s disease patients.

Novel cell lines propel the search for safer stem cell induction

January 20, 2009

Whitehead Institute researchers have reliably produced mice and mouse cell lines with identical configurations of the specific factors needed to reprogram adult cells to an embryonic-stem-cell-like state. These cell lines may be used to screen for potential drug substitutions for the virally-inserted reprogramming genes and as a tool to enhance understanding of how reprogramming works.

Single virus used to convert adult cells to embryonic stem cell-like cells

December 15, 2008

Adult cells, from both humans and mice, can be converted into embryonic stem cell-like cells (induced pluripotent stem cells, or iPS cells) using a single virus to insert four reprogramming genes into the cells’ genomes.

Putting microRNAs on the stem cell map

August 7, 2008

Short snippets of RNA called microRNAs help to keep embryonic stem cells in their stem cell state. Researchers now have discovered the gene circuitry that controls microRNAs in embryonic stem cells.

Recipe for cell reprogramming adds protein

August 6, 2008

Embryonic-like stem cells can be efficiently generated using a natural signaling molecule instead of the virally delivered cancer-causing gene c-Myc.


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