Tag: Protein Function

Schematic of a general signalling pathway

Calculating gene and protein connections in a Parkinson’s model

February 22, 2009

Researchers have created an algorithm that meshes existing data to produce a clearer step-by-step flow chart of how cells respond to stimuli. Using this new method, Whitehead Institute and Massachusetts Institute of Technology scientists have analyzed alpha-synuclein toxicity to identify genes and pathways that can affect cell survival. Misfolded copies of the alpha-synuclein protein in brain cells are a hallmark of Parkinson’s disease.

Photos of healthy greater wax moths and those killed by fungus

The Hsp90-antifungal combo, please: Compromising fungi in the immunocompromised

February 9, 2009

Even the most drug-resistant fungi can be eradicated in multiple in vitro and in vivo models using a lethal combination of an antifungal agent and inhibition of a specific heat shock protein (Hsp90). Such findings could point to a novel approach for the development of future antifungal therapies for patients with compromised immune systems, including HIV, chemotherapy, and organ transfer patients.

Slides of prostate cells

Preventing prostate cancer the complex way

February 2, 2009

Blocking a specific protein complex (mTORC2) prevents prostate tumor formation in mice with a deleted PTEN gene. Inhibition of this complex in normal prostate cells, however, appears to have no effect, suggesting that the protein complex may be a future target for drug development.

Doing the math for membranes

December 4, 2008

A new quantitative model accurately predicts the three-dimensional forces involved in creating and maintaining certain biological membranes.

New clue emerges for cellular damage in Huntington’s disease

November 17, 2008

Huntington’s disease is caused by misfolded and clumped proteins that interfere with the cell’s protein quality control, which may lead to cellular toxicity and eventually cell death.

How cells size up their growth opportunities

May 22, 2008

Improved understanding of this nutrient-sensing pathway may aid in developing therapies for cancer and diabetes.

Photo of Arabidopsis thaliana

Shocking evolution into action

February 18, 2008

One heat shock protein affects the expression of many complex traits genes, which may contribute to rapid evolutionary change.

Scanning electron microscope image of red blood cells

Human blood stem cells are multiplied 20-fold in culture

January 17, 2008

Advance offers promise for bone marrow transplants, gene therapy.

Heat shock proteins are co-opted for cancer

September 20, 2007

A Jekyll-Hyde mechanism that both protects healthy cells and enables cancer cells could be the basis for new cancer-fighting drugs.

Image of microarray

Scientists identify prion's infectious secret

May 9, 2007

Small regions within prions help them change other proteins' shapes.

Schematic showing the electron density of the herpes-specific protein m48

New drug target for herpes viruses?

March 8, 2007

Researchers have solved the complex structure of a recently discovered protein that is found in a wide range of herpes viruses.

Diagram of kinase function

A deeper look at gene control

August 17, 2006

A well-known class of proteins may fill in the dotted lines that connect signal transduction pathways to the genes they regulate.

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