Tag: Genetics + Genomics

Andreas Hochwagen

How yeast chromosomes avoid the bad breaks

August 7, 2011

Whitehead Institute researchers have discovered how yeast cells protect themselves against a novel type of chromosome fragility that occurs in repeated DNA during meiosis—the cell division that produces spores in fungi or eggs and sperm in plants and animals.

Precision gene targeting in stem cells corrects disease-causing mutations

July 14, 2011

Using two distinct methods, Whitehead Institute researchers have successfully and consistently manipulated targeted genes in both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (adult cells that have been reprogrammed to an embryonic stem cell-like state).

Scientists ignore cultural barriers to find the cause of a rare disease

April 11, 2011

In a research collaboration blind to affairs of politics, ethnicity, and religion, an international team led by Israeli scientists has identified the genetic cause of a neurological disorder afflicting members of a Palestinian family.

Emerging drug class may enhance red blood cell production in anemic patients

December 22, 2010

By determining how corticosteroids act to increase production of red blood cell progenitors, Whitehead Institute researchers have identified a class of drugs that may be beneficial in treating some erythropoietin-resistant anemias.

New Whitehead Fellow on the hunt for rare genetic mutations

August 26, 2010

As Whitehead Institute’s newest Fellow, Yaniv Erlich comes to Cambridge in search of rare genetic variants or mutations occurring in individual human genomes.

Graphic of gene expression machinery and the protein complexes Mediator and Cohesin forming a DNA loop

Surprise in genome structure linked to developmental diseases

August 18, 2010

The genes that are responsible for maintaining each cell type form DNA loops that link control elements for these genes. This surprising genome structure is generated and reinforced by two essential protein complexes that bridge the loops and contribute to proper gene regulation.

Human embryonic stem cells and reprogrammed cells virtually identical

August 5, 2010

Human embryonic stem (ES) cells and adult cells reprogrammed to an embryonic stem cell-like state—so-called induced pluripotent stem or iPS cells—exhibit very few differences in their gene expression signatures and are nearly indistinguishable in their chromatin state, according to Whitehead Institute researchers.

How microtubules let go of their attachments during cell division

May 13, 2010

Whitehead Institute researchers have determined a key part of how cells regulate the chromosome/microtubule interface, which is central to proper chromosomal distribution during cell division.

Karyotype of cell with only one copy of each chromosome, except chromosome 8

Knockouts in human cells point to pathogenic targets

November 26, 2009

Whitehead Institute researchers have developed a new approach for genetics in human cells and used this technique to identify specific genes and proteins required for pathogens.

Study reveals connection between genetic and environmental causes of Parkinson’s disease

February 1, 2009

Scientists at the Whitehead Institute for Biomedical Research have found that a single gene, known as PARK9, protects cells from manganese toxicity and rescues neurons from over-expression of the protein alpha-synuclein. Misfolded alpha-synuclein is the hallmark of Parkinson’s disease.

Tracking the molecular pathway to mixed-lineage leukemia

December 15, 2008

The MLL-AF4 fusion protein, which causes the blood cancer called mixed-lineage leukemia (MLL), binds to several genes responsible for early blood cell development. MLL-AF4 also alters the chromatin proteins associated with these genes, a state that is associated with cancer and leukemia progression.

DNA methylation shown to promote development of colon tumors

December 1, 2007

A promising pathway that may lead to prevention, diagnosis and treatment of certain cancers with minimal side effects.

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