Tag: Genetics + Genomics

lobSTR algorithm overview.

lobSTR algorithm rolls DNA fingerprinting into 21st Century

April 27, 2012

Whitehead Institute researchers have created a three-step algorithm, lobSTR, that in one day accurately and simultaneously profiles more than 100,000 short tandem repeats (STRs) in one human genome sequence—a feat that previous systems could never complete.

Image: Y and X chromosomes

Theory of the "rotting" Y chromosome dealt a fatal blow

February 22, 2012

Research on the evolution of the human Y chromosome confirms that the Y—despite arguments to the contrary—has a long, healthy future ahead of it.

Noncoding RNAs alter yeast phenotypes in a site-specific manner

February 14, 2012

A team of scientists from Whitehead Institute and other institutions has shown for the first time how two long intergenic noncoding RNAs (ncRNAs) in brewer’s yeast (Saccharomyces cerevisiae) contribute to a location-dependent switch for the yeast FLO11 gene to toggle between active and inactive states.

Diagram of how chromosomes are aligned

A mitosis mystery solved: how chromosomes align perfectly in a dividing cell

February 12, 2012

Although the process of mitotic cell division has been studied intensely for more than 50 years, Whitehead Institute researchers have only now solved the mystery of how cells correctly align their chromosomes during symmetric mitosis. 

Images of cells with LSD1 activity on and off

Chaos in the cell's command center

February 1, 2012

Whitehead Institute researchers have determined the critical role one enzyme, lysine-specific demethylase 1 (LSD1), plays as mouse embryonic stem cells (ESCs) differentiate.

How major signaling pathways are wired to our genome gives new insight into disease processes

October 27, 2011

Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each cell type and tailor gene expression to control cell state, growth, differentiation, and death.

Yeast cells indicating that Aβ disrupts normal cellular trafficking

Yeast model connects Alzheimer's disease risk and amyloid beta toxicity

October 27, 2011

In a development that sheds new light on the pathology of Alzheimer’s disease (AD), a team of Whitehead Institute scientists has identified connections between genetic risk factors for the disease and the effects of a peptide toxic to nerve cells in the brains of AD patients.

Andreas Hochwagen

How yeast chromosomes avoid the bad breaks

August 7, 2011

Whitehead Institute researchers have discovered how yeast cells protect themselves against a novel type of chromosome fragility that occurs in repeated DNA during meiosis—the cell division that produces spores in fungi or eggs and sperm in plants and animals.

Precision gene targeting in stem cells corrects disease-causing mutations

July 14, 2011

Using two distinct methods, Whitehead Institute researchers have successfully and consistently manipulated targeted genes in both human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells (adult cells that have been reprogrammed to an embryonic stem cell-like state).

Scientists ignore cultural barriers to find the cause of a rare disease

April 11, 2011

In a research collaboration blind to affairs of politics, ethnicity, and religion, an international team led by Israeli scientists has identified the genetic cause of a neurological disorder afflicting members of a Palestinian family.

Emerging drug class may enhance red blood cell production in anemic patients

December 22, 2010

By determining how corticosteroids act to increase production of red blood cell progenitors, Whitehead Institute researchers have identified a class of drugs that may be beneficial in treating some erythropoietin-resistant anemias.

New Whitehead Fellow on the hunt for rare genetic mutations

August 26, 2010

As Whitehead Institute’s newest Fellow, Yaniv Erlich comes to Cambridge in search of rare genetic variants or mutations occurring in individual human genomes.

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