Tag: Sive Lab

Whitehead Member Hazel Sive

MIT and Sierra Leone professors collaborate on education strategy

January 3, 2020

Whitehead Member and MIT Professor Hazel Sive launched MIT-Africa’s short course program

Sive Named Dean at Northeastern University

December 13, 2019

Whitehead Institute Member Hazel Sive, a globally respected developmental biologist and educator, will become Dean of the College of Science at Northeastern University, beginning in June 2020.

Collage of various pets of people at Whitehead Institute

Beyond the Lab Bench: A Look at the Traditions That Make Whitehead Institute Unique

December 10, 2019

The Pets of Whitehead Institute: how pets can keep people working in science tied to the larger world

Illustration of a hairpin loop from a pre-mRNA

Regulatory RNA: The sculptors of gene expression

September 30, 2019

Whitehead Institute scientists have been uncovering the roles of regulatory RNA in controlling gene expression

Image of fish and RNA hairpins

Pairing mismatch helps impaired fish RNA cleavage proceed swimmingly

December 21, 2017

Researchers at Whitehead Institute have uncovered how small changes in the fish Argonaute (Ago) protein, an RNA slicing protein, that happened in its lineage an estimated 300 million years ago greatly diminished the efficiency of RNAi in these animals, while another ancestral feature, in a critical pre-microRNA, was retained that enabled the microRNA to still be produced despite the fish’s impaired Ago protein.

Image of zebrafish

Genetic body/brain connection identified in genomic region linked to autism

October 6, 2017

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes—fam57ba and doc2a—in zebrafish and certain brain and body traits, such as seizures, hyperactivity, large head size, and increased fat content. Both genes reside in the 16p11.2 region of the genome, which has been linked to multiple brain and body disorders in humans, including autism spectrum disorder, developmental delays, seizures, and obesity.

Jaw-dropping research explains mouth formation during embryonic development

August 2, 2016

Whitehead Institute researchers have identified an area in the developing face of embryonic frogs that unzips to form the mouth. The scientists, who named this region the “pre-mouth array”, have also discovered the cellular signaling that triggers its formation. Elucidating this critical aspect of craniofacial development in a model organism enhances understanding of and potential treatment for human facial birth defects.

Implanting beads coated with Bradykinin peptides prevents the abnormal facial phenotypes seen after loss of function in kininogen, part of the Kinin-Kallikreien pathway.

A region and pathway found crucial for facial development in vertebrate embryos

July 17, 2014

A signaling pathway once thought to have little if any role during embryogenesis is a key player in the formation of the front-most portion of developing vertebrate embryos. Moreover, signals emanating from this region—referred to as the “extreme anterior domain” (EAD)—orchestrate the complex choreography that gives rise to proper facial structure.

Images of zebrafish brain development

Fishing for answers to autism puzzle

June 19, 2012

A team of Whitehead Institute and MIT scientists has shown that zebrafish can be a useful tool for studying the genes that contribute to such disorders.

What's in a name? Broadening the biological lexicon to bolster translational research

March 9, 2011

So-called model organisms have long been at the core of biomedical research, allowing scientists to study the ins and outs of human disorders in non-human subjects.

Imges of normal and mutated zebrafish brain ventricles

"Relaxation" a critical step in vertebrate brain development

February 10, 2010

Normal vertebrate brain ventricle formation relies upon the stretchiness or “relaxation” of the neuroepithelium, which is regulated by the motor protein myosin. This process was discovered in zebrafish and may play a role in the proper expansion of tubes in other organs throughout development.

Opening the primary mouth with Wnt antagonists

May 4, 2009

Whitehead researchers have identified a novel mechanism that operates during formation of the “primary mouth”, the first opening between the outside of the embryo and the intestine.

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