Tag: Sabatini Lab

Image:  Computer-generated model of mTORC1

On the path to age-defying therapies

March 29, 2012

By teasing apart rapamycin’s activity at the cellular level, researchers at Whitehead Institute and the University of Pennsylvania have determined that inhibiting only the protein cluster known as the mechanistic target of rapamycin complex 1 (mTORC1) prolongs life in mice without adversely affecting glucose tolerance or insulin sensitivity.

Key metabolic pathway implicated in intractable form of breast cancer

July 18, 2011

Using a new in vivo screening system, Whitehead Institute researchers have identified a protein in a key metabolic pathway that is essential in estrogen receptor (ER)-negative breast cancer.

Scientists discover new component of key growth-regulating signaling pathway

June 10, 2011

Researchers in the lab of Whitehead Institute Member David Sabatini have identified a previously unknown substrate of the mammalian target of rapamycin (mTOR) kinase, called Grb10. Linking Grb10 activity to mTOR provides a more detailed understanding of the function of mTOR and may open up new areas for mTOR research.

Leucine deprivation proves deadly to malignant melanoma cells

May 16, 2011

Whitehead Institute researchers have found that depriving human melanoma cells of the amino acid leucine can be lethal to the cells, suggesting a possible strategy for therapeutic intervention. The researchers observed the effect in melanoma cells with a mutation in the RAS/MEK signaling pathway—the most common mutation found in the deadliest form of skin cancer.

Mammalian aging process linked to overactive cellular pathway

December 22, 2010

Whitehead Institute researchers have linked hyperactivity in the mechanistic target of rapamycin complex 1 (mTORC1) cellular pathway to reduced ketone production in the liver, which is a well-defined physiological trait of aging in mice.

Yasemin Sancak receives Harold M. Weintraub Award

March 11, 2010

Yasemin Sancak, a researcher in the lab of Whitehead Member David Sabatini, has received a 2010 Harold M. Weintraub Graduate Student Award, which honors outstanding biology graduate students for the quality, originality, and significance of their work.

Whitehead Member David Sabatini receives Paul Marks Prize

September 29, 2009

Whitehead Institute Member David Sabatini has been awarded the Paul Marks Prize for Cancer Research in recognition of his discovery of a key pathway regulating cell growth and survival.

Multiple myeloma cells get what they want

May 27, 2009

Researchers at Whitehead Institute for Biomedical Research have identified a protein in multiple myeloma cells, called DEPTOR, that indirectly activates a signaling pathway commonly turned on in cancer cells. Known as the PI3K/PTEN/Akt pathway, this signaling pathway controls cell survival, and when altered, keeps cancer cells from dying.

Cell pathway on overdrive prevents cancer response to dietary restriction

March 11, 2009

Whitehead Institute researchers have pinpointed a cellular pathway that determines whether cancerous tumors are susceptible to dietary restriction during their development. When this pathway, known as PI3K is permanently turned “on” via mutation, tumors grow and proliferate independent of the amount of food consumed. However, when the PI3K pathway operates normally, tumors respond to dietary restriction—defined as food consumption limited to 60% of normal--and become smaller in size.

Slides of prostate cells

Preventing prostate cancer the complex way

February 2, 2009

Blocking a specific protein complex (mTORC2) prevents prostate tumor formation in mice with a deleted PTEN gene. Inhibition of this complex in normal prostate cells, however, appears to have no effect, suggesting that the protein complex may be a future target for drug development.

Whitehead Member David Sabatini wins HHMI appointment

May 27, 2008

Sabatini has been appointed a Howard Hughes Medical Investigator, a highly sought-after post that recognizes the nation’s top biomedical scientists.

How cells size up their growth opportunities

May 22, 2008

Improved understanding of this nutrient-sensing pathway may aid in developing therapies for cancer and diabetes.

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