Tag: Sabatini Lab

This molecule helps sweet-toothed protein complex sense sugar

July 29, 2020

A new study identifies a key step involved in the breakdown of glucose that allows the mTORC1 complex to sense sugar in its environment, leading to a metabolic response in the cell

Collage of people exercising in various ways for the GetFit competition

Beyond the Lab Bench: A Look at the Traditions That Make Whitehead Institute Unique

April 30, 2020

On the 4th floor of Whitehead Institute, scientists have found a unique way to cope with the rainy period of early spring — a competition where teams of eight try to exercise the most minutes. And it has helped a sizable part of the Whitehead community cope with social distancing during the COVID-19 pandemic.

How labs are weathering the lockdown

April 27, 2020

Labs are off-limits for most during the coronavirus pandemic. Here’s what Whitehead Institute scientists are doing to advance basic research, share their knowledge, and keep up morale in unprecedented times.

A split image shows healthy and diseased airway cilia side by side. The healthy cilia are well-defined, the diseased look a little shapeless and stuck together.

From bedside to bench, and back again

April 22, 2020

A mysterious case in the clinic led Whitehead Institute researchers to discover a new genetic lung condition

Whitehead Institute Member David Sabatini Receives the 2020 Sjöberg Prize from the Royal Swedish Academy of Sciences

February 4, 2020

The award recognizes Sabatini’s pathbreaking work on mTOR and cancer metabolism

The FLCN-FNIP-Rag-Ragulator complex

Whitehead team solves structure of key mTORC1 activator

November 5, 2019

Findings shed light on the mechanics of mTORC1 signaling, lay the foundation for drug discovery 

Image of structure of the raptor - rag - ragulator protein comples

Whitehead Institute team resolves structure of master growth regulator

October 10, 2019

New paper in Science reveals how mTORC1 docks at lysosomal surface  


Photo of Whitehead Institute Postdoc Izabella Pena

Whitehead Institute Postdoc Izabella Pena Selected as a 2019 Pew Latin American Fellow

June 10, 2019

Pena, who hails from Brazil, studies in Whitehead Institute Member David Sabatini's lab how cells calibrate their growth, metabolism, and proliferation based on nutrient availability 

Representation of the Zika virus's surface

How to be a good host (for Zika virus)

April 22, 2019

Using a genome-wide CRISPR screen in neural progenitor cells, Whitehead Institute scientists uncover what the Zika virus needs to infect human cells

Illustration of woman shooting at a cancer monster

Sharpening the edges of cancer chemotherapy

July 11, 2018

Whitehead team deploys CRISPR tools to better understand and uncover ways of improving methotrexate, a popular chemotherapy drug.

Image of GATOR1 structure

Structure of key growth regulator revealed

March 28, 2018

Researchers solve molecular structure of GATOR1 complex using cryo-electron microscopy

Illustration of scientist opening a cell and looking at a molecule

Key nutrient sensor identified for cellular pathway linking nutrient availability to cell growth

November 9, 2017

Whitehead Member David Sabatini has identified the methionine sensor in the mTOR pathway, which is a crucial metabolic pathway in cells. His work provides interesting data suggesting that the anti-aging and anti-diabetes effects of low methionine and mTOR inhibition may be connected.

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