Tag: Sabatini Lab

AudioHelicase logo and Whitehead Member David Sabatini

AudioHelicase: The podcast of Whitehead Institute

September 12, 2017

Whitehead's David Sabatini discusses mTOR, a protein connecting metabolism, nutrition, and disease and the current research in his lab investigating the mTOR pathway and its role in cancer, diabetes, and aging.

Growth medium based on human plasma rewires cell metabolism

April 6, 2017

Cultured human cells are the foundation for disease and drug research. Now Whitehead Institute researchers have designed a growth medium that more closely resembles the cells’ environment in the body—and demonstrated that, relative to decades-old recipes that have remained the workhorses of cell culture studies, it significantly alters the cells’ inner workings.

Whitehead Member David Sabatini

Whitehead Member David Sabatini awarded Foundation for the NIH Lurie Prize in Biomedical Sciences

April 4, 2017

Prize bestowed for discovery of the mTOR pathway’s impact on age-related diseases

Researchers chart global genetic interaction networks in human cancer cells

February 2, 2017

Investigators at Whitehead Institute and the Broad Institute have succeeded in identifying the set of essential genes—those required for cellular proliferation and survival—in each of 14 human acute myeloid leukemia (AML) cell lines that had previously been characterized by genome sequencing. By combining their “gene essentiality map” with the existing genomic information, their study revealed liabilities in genetically defined subset of cancers that could be exploited for new therapies.

Microscope images of mitochondria

Novel method enables absolute quantification of mitochondrial metabolites

August 31, 2016

Whitehead Institute scientists have developed a method to quickly isolate mitochondria from mammalian cells and systematically measure the concentrations of mitochondrial metabolites. Mitochondrial dysfunction is found in several disorders, including Parkinson’s disease, cardiovascular disease, and mitochondrial diseases. Until now, peering into the inner metabolic workings of these vital organelles has been very challenging.

Whitehead Institute Members Hidde Ploegh and David Sabatini

Whitehead Members Hidde Ploegh and David Sabatini Elected to National Academy of Sciences

May 3, 2016

The National Academy of Sciences announced today that Whitehead Institute’s Hidde Ploegh and David Sabatini are among 84 new Academy members elected in recognition of distinguished and continuing achievements in original research.

Cartoon of CASTOR1's role in mTORC1 regulation

Scientists identify sensor that modulates key metabolic pathway

March 10, 2016

Whitehead Institute researchers have elucidated how the growth-regulating metabolic pathway known as mTORC1 (for mechanistic target of rapamycin complex 1) senses the amino acid arginine. This nutrient sensor may represent a novel therapeutic target for controlling mTORC1, whose activity is often dysregulated in a variety of diseases, including diabetes and cancer. 

Drawing of unhealthy food

High-fat diet linked to intestinal stem cell changes, increased risk for cancer

March 2, 2016

Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer. Now, a new study from Whitehead Institute and MIT’s Koch Institute for Integrative Cancer Research reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous.

Diagram showing the frequency of mutations in the gene for RagC

Scientists identify mTOR pathway mutations in follicular lymphoma

December 21, 2015

A team of researchers from Whitehead Institute and Queen Mary University of London (QMUL) have identified in follicular lymphoma tumors a mutated protein that could serve as a biomarker to predict therapeutic response.

Diagram of the crystal structure of Cas9 in complex with guide RNA and its target DNA.

Screen of human genome reveals set of genes essential for cellular viability

October 15, 2015

Using two complementary analytical approaches, scientists at Whitehead Institute and Broad Institute of MIT and Harvard have for the first time identified the universe of genes in the human genome essential for the survival and proliferation of human cell lines or cultured human cells. Their findings and the materials they developed in conducting the research will not only serve as invaluable resources for the global research community but should also have application in the discovery of drug-targetable genetic vulnerabilities in a variety of human cancers.

Schematic showing how amino acid inputs control the activity of the growth-regulating mTORC1 pathway

Scientists discover essential amino acid sensor in key growth-regulating metabolic pathway

October 8, 2015

Whitehead Institute scientists have at last answered the long-standing question of how the growth-regulating pathway known as mechanistic target of rapamycin complex 1 (mTORC1) detects the presence of the amino acid leucine—itself a key player in modulating muscle growth, appetite, and insulin secretion.

Diagram of RAB35's role in oncogenesis

New role for an old protein: Cancer causer

September 3, 2015

A protein known to play a role in transporting the molecular contents of normal cells into and out of various intracellular compartments can also turn such cells cancerous by stimulating a key growth-control pathway.

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