Tag: Ploegh Lab

Schematic of YOD1's role

Jamming cell’s protein disposal shows how system works

October 26, 2009

Whitehead Institute scientists have determined that a protein known as YOD1 plays a critical role in the disposal of misfolded cellular proteins. The researchers identified YOD1’s role by blocking its function, a manipulation that halts the elimination of errant proteins entirely. The finding should help bring greater understanding to this vital but complex cellular process.

Scientists pinpoint immune system targets in complex pathogens

December 5, 2008

Scientists have long struggled for details on how the immune system responds to complex pathogens such as the parasite Toxoplasma gondii and herpes viruses. Adapting an existing technology, researchers have pinpointed precise molecular targets that these pathogens present to signal T cells.

Schematic of microengraved slide use

Protein-printing technique gives snapshots of immune system defense

November 3, 2008

A new technique lets researchers, for the first time, look at single white blood cells and measure specific characteristics of the set of antibodies they produce when the body is under attack.

Gijsbert Grotenbreg is named NRF Research Fellow

February 15, 2008

Postdoc will receive up to $1.5 million for independent research in Singapore.

Schematic showing the electron density of the herpes-specific protein m48

New drug target for herpes viruses?

March 8, 2007

Researchers have solved the complex structure of a recently discovered protein that is found in a wide range of herpes viruses.

Diagram of protein being ejected from a cell

Virus yields clues into immune system

May 31, 2006

Ploegh lab discovers a key component in the machinery with which cells dispose of misfolded proteins.

Photo: Princess Mathilde and Whitehead Member Hidde Ploegh

Ploegh wins Belgian health prize

May 11, 2006

The Interbrew-Baillet Latour Health Prize, worth 150,000 euros, is the largest scientific prize awarded in Belgium.

Signals for war

November 16, 2005

Your immune system is an army on full alert. How does it recognize the enemy when it's under attack?

Hidde Ploegh joins Whitehead Institute faculty

March 30, 2005

Molecular biologist Hidde Ploegh has just been appointed to the faculty of Whitehead Institute for Biomedical Research.

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