Tag: Lindquist Lab

Image of microarray

Scientists identify prion's infectious secret

May 9, 2007

Small regions within prions help them change other proteins' shapes.

Whitehead researchers named among Scientific American’s top 50

November 6, 2006

Whitehead Members Susan Lindquist and Richard Young, along with postdoctoral scientist Laurie Boyer, have been named in Scientific American magazine’s annual list of the world’s 50 top leaders in research, business or policy.

Lindquist and Jaenisch elected to Institute of Medicine

October 12, 2006

Election is considered one of the highest honors in the fields of medicine and health.

Image of yeast cells epxressing alpha-synuclein

Researchers reverse Parkinson's symptoms in animal models

June 22, 2006

They repaired a key biological pathway, restoring normal neurological function.

Susan Lindquist wins HHMI appointment

May 16, 2006

Lindquist will remain at Whitehead Institute while HHMI employs her and funds a large percentage of her research.

Mad-cow protein aids creation of brain cells

February 13, 2006

The protein ultimately responsible for mad cow disease might be necessary for healthy brain function.

Mad-cow culprit maintains stem cells

January 30, 2006

The same protein that causes neurodegenerative conditions such as bovine spongiform encephalopathy (mad cow disease) is also important for helping certain adult stem cells maintain themselves.

Within the folds, outside the box

October 26, 2005

Feverishly hot climates. Dizzying alcohol and sugar binges. Heavy metals. Toxic drugs. Genetic mutations. Over the years, yeast, fruit flies, mustard plants and mice have struggled through their own versions of an extreme reality TV show in the laboratory of Whitehead Member Susan Lindquist.

Pathogenic fungi reveal new mechanism for evolution

September 29, 2005

Researchers in the laboratory of Whitehead Member Susan Lindquist have identified a key mechanism that enables pathogenic fungi to evolve drug-resistant capabilities with such distressing rapidity.

Leah Cowen awarded Genzyme Fellowship

September 21, 2005

Leah Cowen, a postdoctoral fellow in the lab of Whitehead Member Susan Lindquist, has been selected by a Whitehead committee to receive the Genzyme Postdoctoral Fellowship at Whitehead Institute.

Image: Diagrams of protein fibers

Unweaving amyloid fibers to solve prion puzzles

June 8, 2005

Amyloid fibers are best known as the plaque that gunks up neurons in people with neurodegenerative illnesses such as Alzheimer’s and Creutzfeldt-Jacob disease—the human analog of mad cow disease. But even though amyloids are common and implicated in a host of conditions, researchers haven’t been able to identify their precise molecular structures.

Prions act as stepping stones in evolution

August 18, 2004

When a protein misfolds, the results can be disastrous. An incorrect change in the molecule’s shape can lead to diseases including Alzheimer’s and Huntington’s. But scientists have discovered that misfolded proteins can have a positive side in yeast.

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