Tag: Lindquist Lab

Schematic of a general signalling pathway

Calculating gene and protein connections in a Parkinson’s model

February 22, 2009

Researchers have created an algorithm that meshes existing data to produce a clearer step-by-step flow chart of how cells respond to stimuli. Using this new method, Whitehead Institute and Massachusetts Institute of Technology scientists have analyzed alpha-synuclein toxicity to identify genes and pathways that can affect cell survival. Misfolded copies of the alpha-synuclein protein in brain cells are a hallmark of Parkinson’s disease.

Photos of healthy greater wax moths and those killed by fungus

The Hsp90-antifungal combo, please: Compromising fungi in the immunocompromised

February 9, 2009

Even the most drug-resistant fungi can be eradicated in multiple in vitro and in vivo models using a lethal combination of an antifungal agent and inhibition of a specific heat shock protein (Hsp90). Such findings could point to a novel approach for the development of future antifungal therapies for patients with compromised immune systems, including HIV, chemotherapy, and organ transfer patients.

Study reveals connection between genetic and environmental causes of Parkinson’s disease

February 1, 2009

Scientists at the Whitehead Institute for Biomedical Research have found that a single gene, known as PARK9, protects cells from manganese toxicity and rescues neurons from over-expression of the protein alpha-synuclein. Misfolded alpha-synuclein is the hallmark of Parkinson’s disease.

Photos of yeast plates

Misfolded proteins accelerate yeast evolution

November 25, 2008

In yeast, a protein-misfolding mechanism can reveal hidden genetic variations and thus generate new phenotypes that may increase cell survival. Researchers now have demonstrated that when yeast cells are stressed, this mechanism is triggered much more often.

Susan Lindquist wins HHMI Collaborative Innovation Award

November 20, 2008

Whitehead Member and Howard Hughes Medical Institute (HHMI) investigator Susan Lindquist has been awarded a Collaborative Innovation Award, part of a four year, $40 million pilot project launched by the HHMI.

New clue emerges for cellular damage in Huntington’s disease

November 17, 2008

Huntington’s disease is caused by misfolded and clumped proteins that interfere with the cell’s protein quality control, which may lead to cellular toxicity and eventually cell death.

Whitehead’s Luke Whitesell receives top research grant from Johnson & Johnson

October 10, 2008

Whitesell has been chosen to participate in Johnson & Johnson’s Focused Funding Program.

Whitehead Member Susan Lindquist honored with Harvard Centennial Medal

June 4, 2008

Whitehead Member Susan Lindquist has been awarded a Graduate School of Arts and Sciences (GSAS) Centennial Medal from Harvard University, given annually to graduate alumni who have made exceptional contributions to society.

Susan Lindquist receives Otto Warburg Medal

March 27, 2008

Award recognizes contributions to understanding of neurological disease.

Photo of Arabidopsis thaliana

Shocking evolution into action

February 18, 2008

One heat shock protein affects the expression of many complex traits genes, which may contribute to rapid evolutionary change.

Susan Lindquist receives Genetics Society of America Medal

February 5, 2008

The medal is given for outstanding contributions in the field of genetics during the past 15 years.

Heat shock proteins are co-opted for cancer

September 20, 2007

A Jekyll-Hyde mechanism that both protects healthy cells and enables cancer cells could be the basis for new cancer-fighting drugs.

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