Tag: Lindquist Lab

Image: Yeast with prions grow better than those without when challenged with an antifungal drug

Prions play powerful role in the survival and evolution of wild yeast strains

February 15, 2012

In a massive undertaking, Whitehead Institute scientists have tested nearly 700 wild yeast strains isolated from diverse environments for the presence of known and unknown prion elements, finding them in one third of all strains. All the prions appear capable of creating diverse new traits, nearly half of which are beneficial.

Breast tissue showing both breast cancer cells and normal breast epithelial cells

High levels of master heat shock protein linked to poor prognosis in breast cancer patients

October 31, 2011

Whitehead Institute scientists report that patients whose estrogen receptor (ER)-positive breast cancers have high levels of an ancient cellular survival factor experience poor outcomes—including increased mortality.

Yeast cells indicating that Aβ disrupts normal cellular trafficking

Yeast model connects Alzheimer's disease risk and amyloid beta toxicity

October 27, 2011

In a development that sheds new light on the pathology of Alzheimer’s disease (AD), a team of Whitehead Institute scientists has identified connections between genetic risk factors for the disease and the effects of a peptide toxic to nerve cells in the brains of AD patients.


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MIT Professor Susan Lindquist

February 16, 2011

Professor Susan Lindquist remembers unexpected moments that changed her life's direction and helped her create a career in the sciences. Lindquist, a member of the Whitehead Institute for Biomedical Research and an MIT biology professor, received the National Medal of Science in 2010. This interview is part of a video installation in the Koch Institute Public Galleries, where visitors can explore current cancer research projects and hear first-person reflections on cancer.

Heat shock protein drives yeast evolution

December 23, 2010

Whitehead Institute researchers have determined that heat shock protein 90 (Hsp90) can create diverse heritable traits in brewer’s yeast (Saccharomyces cerevisiae) by affecting a large portion of the yeast genome.

Whitehead Member Susan Lindquist honored with Mendel Medal

November 12, 2010

Whitehead Member Susan Lindquist has been awarded the Mendel Medal by the Genetics Society in the U.K.

Whitehead Member Susan Lindquist awarded Max Delbrück Medal

November 4, 2010

Whitehead Institute Member Susan Lindquist has received the Max Delbrück Medal in Berlin, Germany, for her work on protein folding.

Lindquist shaking Obama's hand

Whitehead Member Susan Lindquist to Receive National Medal of Science

October 15, 2010

President Obama today named Whitehead Member Susan Lindquist a recipient of the National Medal of Science, the nation’s highest scientific honor.

Microscope image of the transitional phase of yeast prions

A different tune: cellular IPOD plays role in prion biology

April 26, 2010

According to Whitehead Institute researchers, cells take advantage of a biologically ancient compartment to sequester prions, an action that can initially prevent the prions’ phenotypic expression. While in this compartment, less stably heritable prion plaques also mature to a more transmissible state.

Yeast overproducing alpha-synuclein

Small molecules found to protect cells in multiple models of Parkinson’s disease

December 28, 2009

Several structurally similar small molecules appear capable of protecting cells from alpha-synuclein toxicity, a hallmark of Parkinson’s disease, according to Whitehead Institute researchers.

Gene mutation alone causes transmissible prion disease

August 26, 2009

Whitehead Institute researchers have shown definitively that mutations associated with prion diseases are sufficient to cause a transmissible neurodegenerative disease. Deciphering the origins of prion diseases could help farmers and policy-makers determine how best to control a prion disease outbreak in livestock and to prevent prion transmission to humans.

Redefining what it means to be a prion

April 2, 2009

Whitehead Institute researchers have found a large number of new prions, greatly expanding scientists’ notion of how important prions might be in normal biology and demonstrating that they play many and varied roles in the inheritance of biological traits.

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