Retinoic acid regulates transitions in mouse sperm production
November 7, 2017
Researchers swimming upstream in reproductive technology work now have important insights into sperm production
A new workflow for natural product characterization comes ashore with red algae
October 30, 2017
Whitehead Member Jing-Ke Weng uses an omics-based path for identifying and generating sesquiterpene-based therapeutics at scale.
Small worm muscles up to reveal ancient body patterning mechanism during regeneration
October 30, 2017
Whitehead Member Peter Reddien has determined that a major function of muscle in planaria and acoels--a small regenerative marine worm auspiciously located on the evolutionary tree as an outgroup to all the rest of the Bilateria--is to serve as the source of instructive positional information for instructing regeneration.
AudioHelicase: NASA Astronaut and Former Whitehead Fellow Kathleen "Kate" Rubins
October 23, 2017
NASA Astronaut and Former Whitehead Fellow Kathleen "Kate" Rubins discusses her journey from studying pox viruses to sequencing DNA in space.
Stuck on the membrane: A pro-metastatic transcription factor’s journey from anonymity to a promising target for breast cancer therapy
October 20, 2017
Whitehead Member Piyush Gupta has identified a protein stuck in the cell membrane that plays an important role in a cellular pathway crucial for cancer metastasis. The protein is a potential new target for breast cancer therapy that targets the cancer cells' metastatic behavior.
Study reveals key molecular link in major cell growth pathway
October 19, 2017
A team of scientists led by Whitehead Institute has uncovered a surprising molecular link that connects how cells regulate growth with how they sense and make available the nutrients required for growth. The researchers’ findings also implicate a new protein, SLC38A9, as a potential drug target in pancreatic cancer.
Genetic body/brain connection identified in genomic region linked to autism
October 6, 2017
For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes—fam57ba and doc2a—in zebrafish and certain brain and body traits, such as seizures, hyperactivity, large head size, and increased fat content. Both genes reside in the 16p11.2 region of the genome, which has been linked to multiple brain and body disorders in humans, including autism spectrum disorder, developmental delays, seizures, and obesity.
Whitehead Connects: An Evening with Nasa Astronaut Kathleen Rubins
September 20, 2017
Whitehead Connects: An Evening With NASA Astronaut Kathleen Rubins
September 15, 2017
Whitehead Connects was pleased to welcome NASA astronaut and former Whitehead Fellow Kathleen “Kate” Rubins on September 12, 2017.
AudioHelicase Podcast: Whitehead's David Sabatini discusses mTOR, a protein connecting metabolism, nutrition, and disease
September 12, 2017
Whitehead's David Sabatini discusses mTOR, a protein connecting metabolism, nutrition, and disease and the current research in his lab investigating the mTOR pathway and its role in cancer, diabetes, and aging.
Mystery solved: how thyroid hormone prods red blood cell production
September 5, 2017
For more than a century, the link between thyroid hormone and red blood cell production has remained elusive. Now, Whitehead scientists have teased about the mechanism that connects them, which could help scientists identify new therapies for specific types of anemia.
In Memoriam: Landon T. Clay
July 31, 2017
The Whitehead Institute community has lost Landon Clay, a true friend and an avid supporter of the Institute’s scientific mission and research.