News Archive

 

Whitehead Institute Founding Member Robert Weinberg

Whitehead’s Weinberg among those earning cancer research group’s highest honor

March 25, 2013

The American Association for Cancer Research (AACR) is including Whitehead Institute Founding Member Robert Weinberg in its inaugural class of Fellows of the AACR Academy.

Whitehead Institute Founding Member Robert Weinberg

Whitehead’s Robert Weinberg to receive new Breakthrough Prize in Life Sciences

February 20, 2013

Whitehead Institute Founding Member Robert Weinberg is among 11 scientists to receive the new Breakthrough Prize in Life Sciences, intended to recognize excellence in research aimed at curing intractable diseases and extending human life.

Model of mitochondrion

Engineering cells for more efficient biofuel production

February 17, 2013

Whitehead Institute and MIT chemical engineers and biologists have now devised a way to dramatically boost isobutanol production in yeast, which naturally make it in small amounts. They engineered yeast so that isobutanol synthesis takes place entirely within mitochondria, cell structures that generate energy and also host many biosynthetic pathways.

Long noncoding RNAs control development of fat cells

February 13, 2013

Whitehead Institute researchers report that 10 long noncoding RNAs (lncRNAs) play a vital role in the regulation of white fat cells. When each of these lncRNAs is individually knocked down, fat precursor cells fail to mature into white fat cells and have significantly reduced lipid droplets compared with white fat cells with unmodified lncRNA function.

Diagrm of transcription of mRNA and lncRNA that start at the same location

Paired genes in stem cells shed new light on gene organization and regulation

February 4, 2013

Research from Whitehead Institute shows that transcription at the active promoters of protein-coding genes commonly runs in opposite directions. This leads to coordinate production of both protein-coding messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs).

Whitehead Founding Member Gerald Fink

Whitehead Founding Member Gerald Fink announced as President-elect of AAAS

January 25, 2013

The American Association for the Advancement of Science (AAAS) today announced that Whitehead Institute Founding Member Gerald R. Fink has been chosen as its President-elect for 2013.

Information security image

Scientists expose new vulnerabilities in the security of personal genetic information

January 17, 2013

Using only a computer, an Internet connection, and publicly accessible online resources, a team of Whitehead Institute researchers has been able to identify nearly 50 individuals who had submitted personal genetic material as participants in genomic studies. 

Representation of MHV-68

Modified antibodies trigger immune response, point to novel vaccine design strategies

January 7, 2013

In an approach with the potential to aid therapeutic vaccine development, Whitehead Institute scientists have shown that enzymatically modified antibodies can be used to generate highly targeted, potent responses from cells of the immune system.

Image of autophage markers in cells with and without RagA activated

Nutrient-sensing enzymes key to starvation response and survival in newborn mammals

December 23, 2012

One enzyme, RagA, has been found to regulate the mechanistic target of rapamycin complex 1 (mTORC1) pathway in cells according to glucose and amino acid availability. When this regulation breaks down in fasting newborn mice, the animals suffer a nutritional crisis and die.

Graphical explanation of MCT1's role in 3-BrPA's uptake by some cancer cells

Cell surface transporters exploited for cancer drug delivery

December 2, 2012

According to Whitehead Institute researchers, a protein known as monocarboxylate transporter 1 (MCT1), which is highly expressed in a subset of metabolically altered cancer cells, is needed for the entry of the investigational cancer drug 3-bromopyruvate (3-BrPA) into malignant cells.

Charts of global genetic analyses

Whitehead scientists identify major flaw in standard approach to global gene expression analysis

October 25, 2012

Whitehead Institute researchers report that common assumptions employed in the generation and interpretation of data from global gene expression analyses can lead to seriously flawed conclusions about gene activity and cell behavior in a wide range of current biological research.

Electron micrograph of egg and sperm

Study reveals rate at which key genetic deletions contribute to male infertility

October 25, 2012

A large-scale analysis of Y chromosomes from more than 20,000 men finds that two spontaneously recurring deletions along a complex region of the Y chromosome are responsible for approximately 8% of cases of failed sperm production.

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