News Archive

 

Ancient gene gives planarians a heads-up in regeneration

May 12, 2011

A little-studied gene known as notum plays a key role in the planarian’s regeneration decision-making process, according to Whitehead Institute scientists. At head-facing (anterior) wounds, the gene notum acts as a dimmer switch to dampen the Wnt pathway—an ancient signaling circuit that operates in all animals—and promote head regeneration.

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Pluripotent adult stem cells power planarian regeneration

May 12, 2011

Whitehead Institute researchers have determined that the planarian flatworm regenerates missing tissues by using pluripotent adult stem cells. Until now, scientists could not determine whether the dividing cells in planarians, called neoblasts, are a mixture of specialized stem cells that each regenerates specific tissues, or if individual neoblasts are pluripotent and able to regenerate all tissues.

Whitehead Member David Bartel elected to National Academy of Sciences

May 3, 2011

The National Academy of Sciences has announced that Whitehead Institute's David Bartel is among 72 new Academy members elected today in recognition of distinguished and continuing achievements in original research.

Two unsuspected proteins may hold the key to creating artificial chromosomes

April 28, 2011

Whitehead Institute scientists report that two proteins once thought to have only supporting roles, are the true “stars” of the kinetochore assembly process in human cells.

Whitehead Institute Director honored with March of Dimes Prize

April 21, 2011

Whitehead Institute Director David Page has been named a recipient of the 2011 March of Dimes Prize in Developmental Biology. The prize honors Page’s groundbreaking body of research on the human Y chromosome.

Scientists ignore cultural barriers to find the cause of a rare disease

April 11, 2011

In a research collaboration blind to affairs of politics, ethnicity, and religion, an international team led by Israeli scientists has identified the genetic cause of a neurological disorder afflicting members of a Palestinian family.

Scientists identify a surprising new source of cancer stem cells

April 11, 2011

Certain differentiated cells in breast tissue can spontaneously convert to a stem-cell-like state, according to Whitehead Institute researchers. Until now, scientific dogma has stated that differentiation is a one-way path; once cells specialize, they cannot return to the flexible stem-cell state on their own.

Whitehead scientist helps revisit "Hallmarks of Cancer"

March 16, 2011

Renowned cancer researchers Robert Weinberg and Douglas Hanahan and have updated the “Hallmarks of Cancer”, their seminal review that codified the traits that all cancers have in common.  The original article has greatly influenced scientists, both in and outside cancer research. The revised work incorporates information gleaned from the past eleven years of cancer research and is expected to have a profound impact on the study of cancer and the quest for approaches to treat it.

What's in a name? Broadening the biological lexicon to bolster translational research

March 9, 2011

So-called model organisms have long been at the core of biomedical research, allowing scientists to study the ins and outs of human disorders in non-human subjects.

Novel method could improve the performance of proteins used therapeutically

March 9, 2011

Whitehead Institute scientists have created a method that uses the enzyme sortase A to site-specifically modify proteins. Using this technique, researchers were able to increase potency, slow the metabolism, and improve thermal stability of several proteins.

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Back on top: Whitehead reclaims title as best place for postdocs to work

March 1, 2011

For the second time in three years, Whitehead Institute has been named the best place in the country for postdoctoral researchers to work.

Whitehead Member Rudolf Jaenisch honored for groundbreaking stem cell research

February 15, 2011

Israel’s Wolf Foundation, whose stated mission is “to promote science and art for the benefit of mankind,” has named Whitehead Institute Founding Member Rudolf Jaenisch a recipient of the prestigious 2011 Wolf Prize in Medicine.

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