News Archive

 

Aggressive cancer exploits MYC oncogene to amplify global gene activity

September 27, 2012

Whitehead Institute researchers have determined the mechanism used by c-Myc to increase the expression of all active genes in cancer cells. Elevated levels of c-Myc are linked to increased rates of metastasis, disease recurrence, and mortality in cancer patients. Guided by this new model, researchers hope to find ways to restrict c-Myc's activity to eradicate cancer cells that become dependent on c-Myc for their survival.

Image of mouse embryonic fibroblasts undergoing reprogramming

Whitehead scientists bring new efficiency to stem cell reprogramming

September 13, 2012

New genetic markers identified by researchers at Whitehead Institute and MIT could help make the process for reprogramming regular body cells into pluripotent stem cells more efficient, allowing scientists to predict which treated cells will successfully become pluripotent.

Logo of NIH Director's Pioneer Award

Whitehead Member to receive NIH grant for "high-risk, high-reward" research

September 13, 2012

Whitehead Institute Member Hidde Ploegh has been named a recipient of a 2012 National Institutes of Health (NIH) Director’s Pioneer Award, intended to accelerate the pursuit of potentially groundbreaking research.

Photo of Mary Gehring

Whitehead Member Mary Gehring receives prestigious young investigator award

September 6, 2012

Whitehead Member Mary Gehring has been selected as a recipient of the Rosalind Franklin Young Investigator Award, funded by The Peter and Patricia Gruber Foundation and administered by a joint committee appointed by the Genetics Society of America and the American Society of Human Genetics.

Image of induced embryonic Sertoli-like cells in the fetal male mouse gonad

Scientists create germ cell-supporting embryonic Sertoli-like cells from skin cells

September 6, 2012

Using a stepwise trans-differentiation process, Whitehead Institute researchers have turned skin cells into embryonic Sertoli-like cells.

Cartoon of cyclin D3's role

Protein found to regulate red blood cell size and number

August 28, 2012

By examining the results of genome-wide association studies (GWAS) in conjunction with experiments on mouse and human red blood cells (RBCs), researchers in the lab of Whitehead Institute Founding Member Harvey Lodish have identified the protein cyclin D3 as regulating the number of cell divisions RBC progenitors undergo, which ultimately affects the resulting size and quantity of RBCs.

Microscope images of samples extracted from cancer tumors and adjacent tissues

Heat-shock factor reveals its unique role in supporting highly malignant cancers

August 2, 2012

Whitehead Institute researchers have found that an ancient, highly conserved cell survival factor drives expression of a specific set of genes that is strongly associated with metastasis and death in patients with breast, colon, and lung cancers.

Images of planarians, one with eye spots and one missing eye spots due to repression of the ovo gene

Planarians offer a better view of eye development

August 2, 2012

Whitehead Institute researchers have created a complete catalog of genes active in the planarian eye. Several identified genes are known to have versions that play a role in the vertebrate eye, including genes involved in eye development and others associated with age-related macular degeneration and Usher syndrome, a disorder that causes progressive retinal degradation.

Model of eukaryotic argonaute protein

Structure of RNAi complex now crystal clear

June 20, 2012

Researchers at Whitehead Institute and Memorial Sloan-Kettering Cancer Center have defined and analyzed the crystal structure of a yeast Argonaute protein bound to RNA.

Images of zebrafish brain development

Fishing for answers to autism puzzle

June 19, 2012

A team of Whitehead Institute and MIT scientists has shown that zebrafish can be a useful tool for studying the genes that contribute to such disorders.

Schematic diagram of the Hsp90 protein.

Breast cancer clinical trial to test combination of heat shock protein inhibitor and hormonal therapy

May 22, 2012

A clinical trial involving collaboration between researchers at Whitehead Institute and Dana Farber Cancer Institute is now enrolling patients with recurrent or metastatic estrogen receptor-positive (ER+) breast cancer.

Whitehead Member Richard Young elected to National Academy of Sciences

May 1, 2012

The National Academy of Sciences announced today that Whitehead Institute’s Richard Young is among 84 new Academy members elected in recognition of distinguished and continuing achievements in original research.

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