News Archive

 

Graphical explanation of MCT1's role in 3-BrPA's uptake by some cancer cells

Cell surface transporters exploited for cancer drug delivery

December 2, 2012

According to Whitehead Institute researchers, a protein known as monocarboxylate transporter 1 (MCT1), which is highly expressed in a subset of metabolically altered cancer cells, is needed for the entry of the investigational cancer drug 3-bromopyruvate (3-BrPA) into malignant cells.

Charts of global genetic analyses

Whitehead scientists identify major flaw in standard approach to global gene expression analysis

October 25, 2012

Whitehead Institute researchers report that common assumptions employed in the generation and interpretation of data from global gene expression analyses can lead to seriously flawed conclusions about gene activity and cell behavior in a wide range of current biological research.

Electron micrograph of egg and sperm

Study reveals rate at which key genetic deletions contribute to male infertility

October 25, 2012

A large-scale analysis of Y chromosomes from more than 20,000 men finds that two spontaneously recurring deletions along a complex region of the Y chromosome are responsible for approximately 8% of cases of failed sperm production.

Franklin Insitute logo

Whitehead Member named a 2013 Franklin Institute Laureate

October 22, 2012

The Franklin Institute of Philadelphia today named Whitehead Institute Founding Member Rudolf Jaenisch one of eight 2013 Laureates—esteemed individuals honored for their pioneering achievements in science, technology, and business leadership.

New video depicts human migration across generations

October 18, 2012

A new video created by Whitehead Institute in collaboration with the genealogical website Geni.com shows the births of millions people, from the Middle Ages through the early 20th Century, as single dots on a black background.

Image: Proposed Skolkovo Institute buildings

Whitehead Members to help establish international stem cell research center

October 1, 2012

Three Members of the Whitehead Institute faculty are poised to play significant roles in the establishment of a new stem cell research center based at Skolkovo Institute of Science and Technology (Skolkovo Tech) in suburban Moscow.

Gabriel Victora

Whitehead Fellow receives prestigious NIH Early Independence Award

September 28, 2012

Whitehead Fellow Gabriel Victora has been named a recipient of a 2012 National Institutes of Health (NIH) Director’s Early Independence Award, aimed at accelerating the careers of exceptionally creative junior scientists.

Aggressive cancer exploits MYC oncogene to amplify global gene activity

September 27, 2012

Whitehead Institute researchers have determined the mechanism used by c-Myc to increase the expression of all active genes in cancer cells. Elevated levels of c-Myc are linked to increased rates of metastasis, disease recurrence, and mortality in cancer patients. Guided by this new model, researchers hope to find ways to restrict c-Myc's activity to eradicate cancer cells that become dependent on c-Myc for their survival.

Image of mouse embryonic fibroblasts undergoing reprogramming

Whitehead scientists bring new efficiency to stem cell reprogramming

September 13, 2012

New genetic markers identified by researchers at Whitehead Institute and MIT could help make the process for reprogramming regular body cells into pluripotent stem cells more efficient, allowing scientists to predict which treated cells will successfully become pluripotent.

Logo of NIH Director's Pioneer Award

Whitehead Member to receive NIH grant for "high-risk, high-reward" research

September 13, 2012

Whitehead Institute Member Hidde Ploegh has been named a recipient of a 2012 National Institutes of Health (NIH) Director’s Pioneer Award, intended to accelerate the pursuit of potentially groundbreaking research.

Photo of Mary Gehring

Whitehead Member Mary Gehring receives prestigious young investigator award

September 6, 2012

Whitehead Member Mary Gehring has been selected as a recipient of the Rosalind Franklin Young Investigator Award, funded by The Peter and Patricia Gruber Foundation and administered by a joint committee appointed by the Genetics Society of America and the American Society of Human Genetics.

Image of induced embryonic Sertoli-like cells in the fetal male mouse gonad

Scientists create germ cell-supporting embryonic Sertoli-like cells from skin cells

September 6, 2012

Using a stepwise trans-differentiation process, Whitehead Institute researchers have turned skin cells into embryonic Sertoli-like cells.

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