Scientists discover RNA modifications in some unexpected places
September 15, 2014
Deploying sophisticated high-throughput sequencing technology, dubbed ψ-seq, a team of Whitehead Institute and Broad Institute researchers collaborated on a comprehensive, high-resolution mapping of ψ sites that confirms pseudouridylation, the most common post-transcriptional modification, does indeed occur naturally in mRNA.
New reprogramming factor cocktail produces therapy-grade induced pluripotent stem cells
September 4, 2014
Induced pluripotent stem cells (iPSCs) may hold the potential to cure damaged nerves, regrow limbs and organs, and perfectly model a patient’s particular disease. Yet these cells can acquire serious genetic and epigenetic abnormalities that lower the cells’ quality and limit their therapeutic usefulness. Now Whitehead Institute researchers have identified a cocktail of reprogramming factors that produces very high quality iPSCs.
TENURE TRACK FACULTY POSITION AT WHITEHEAD INSTITUTE AND DEPARTMENT OF BIOLOGY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
August 26, 2014
The Whitehead Institute and Department of Biology at M.I.T. are seeking an outstanding scientist for a tenure track faculty position at the Assistant Professor level.
Master heat-shock factor supports reprogramming of normal cells to enable tumor growth and metastasis
July 31, 2014
Long associated with enabling the proliferation of cancer cells, the ancient cellular survival response regulated by Heat-Shock Factor 1 (HSF1) can also turn neighboring cells in their environment into co-conspirators that support malignant progression and metastasis.
Innovative scientists update old-school pipetting with new-age technology
July 30, 2014
A team of Whitehead Institute researchers is bringing new levels of efficiency and accuracy to one of the most essential albeit tedious tasks of bench science: pipetting.
Whitehead Institute researchers create “naïve” pluripotent human embryonic stem cells
July 24, 2014
Embryonic stem cell (ESC) research has been hampered by the inability to transfer research and tools from mouse ESC studies to their human counterparts, in part because human ESCs are “primed” and slightly less plastic than the mouse cells. Now researchers in the lab of Whitehead Institute Founding Member Rudolf Jaenisch have discovered how to manipulate and maintain human ESCs into a “naïve” or base pluripotent state similar to that of mouse ESCs without the use of any reprogramming factors.
A region and pathway found crucial for facial development in vertebrate embryos
July 17, 2014
A signaling pathway once thought to have little if any role during embryogenesis is a key player in the formation of the front-most portion of developing vertebrate embryos. Moreover, signals emanating from this region—referred to as the “extreme anterior domain” (EAD)—orchestrate the complex choreography that gives rise to proper facial structure.
Faithful cell division requires tightly controlled protein placement at the centromeres
July 17, 2014
The protein CENP-A, which is integrated into human DNA at the centromere on each chromosome, has a vital role in cell division. Work from Whitehead Institute Member Iain Cheeseman’s lab describes how the vital and tightly controlled replenishment of CENP-A progresses.
Engineered red blood cells could carry precious therapeutic cargo
June 30, 2014
Whitehead Institute scientists have genetically and enzymatically modified red blood cells to carry a range of valuable payloads—from drugs, to vaccines, to imaging agents—for delivery to specific sites throughout the body.
Whitehead Member Jing-Ke Weng named a Pew Scholar
June 24, 2014
The Pew Charitable Trusts has named Whitehead Institute Member Jing-Ke Weng a 2014 Pew Scholar in the Biomedical Sciences.
Seemingly invincible cancer stem cells reveal a weakness
June 5, 2014
Metastatic cancer cells, which can migrate from primary tumors to seed new malignancies, have thus far been resistant to the current arsenal of anticancer drugs. Now, however, researchers at Whitehead Institute have identified a critical weakness that actually exploits one of these cells’ apparent strengths—their ability to move and invade tissues. Their research could inform novel approaches to screening tumors for personalized therapy or to drugs that specifically target these cells.
Lost in translation? Not when it comes to control of gene expression during Drosophila development
May 29, 2014
The lab of Whitehead Member Terry Orr-Weaver has conducted perhaps the most comprehensive look yet at changes in translation and protein synthesis during a developmental change, using the oocyte-to-embryo transition in Drosophila as a model system. One of the insights from this research is that a surprisingly large number of mRNAs that are translationally regulated.