News Archive

 

Slides of tagged cells

Cellular recycling complexes may hold key to chemotherapy resistance

September 2, 2015

Upsetting the balance between protein synthesis, misfolding, and degradation drives cancer and neurodegeneration. Recent cancer treatments take advantage of this knowledge with a class of drugs that block protein degradation, known as proteasome inhibitors. Widespread resistance to these drugs limits their success, but Whitehead researchers have discovered a potential Achilles heel in resistance. With such understandings researchers may be able to target malignancy broadly, and more effectively.

Picture of Whitehead Institute

Tenure track faculty position at Whitehead Institute and Department of Biology, Massachusetts Institute of Technology

September 1, 2015

Whitehead Institute and Department of Biology at M.I.T. are seeking an outstanding scientist for a tenure track faculty position at the Assistant Professor level. 

Diagram of CDPK1 in its active and inactive forms

Tiny antibodies point to vulnerability in disease-causing parasites

August 24, 2015

By teasing apart the structure of an enzyme vital to the parasites that cause toxoplasmosis and malaria, Whitehead Institute scientists have identified a potentially ‘drugable’ target that could prevent parasites from entering and exiting host cells.

Photo of CampBio students

Amgen Foundation grant bolsters Whitehead Institute’s science education programs for middle school students

August 11, 2015

Whitehead Institute has strengthened its popular science education programs for middle schoolers this year thanks to a new grant from the Amgen Foundation.

Electron microscope image of a mitochondrion

Amino acid shortage curbs proliferation in cells with mitochondrial dysfunction

July 31, 2015

According to Whitehead Institute researchers, cells with malfunctioning mitochondria are unable to proliferate due to a shortage of the amino acid aspartate, not because of an energy crisis, as was once thought. Mitochondrial dysfunction plays a role in a host of relatively rare disorders as well as neurodegenerative disorders, including Parkinson’s disease.

Forks colliding: How DNA breaks during re-replication

June 4, 2015

Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, Whitehead Institute scientists are bringing new clarity to the causes of such genomic damage. Moreover, because errors arising during DNA replication and gene amplification result in chromosomal abnormalities often found in malignant cells, these new findings may bolster our understandings of certain drivers of cancer progression.

Image of human red blood cells

Repurposed anti-cholesterol drug could improve treatment-resistant anemias

May 11, 2015

Using a mouse model, the lab of Whitehead Institute Founding Member Harvey Lodish, has now determined that combining the cholesterol-lowering drug fenofibrate with glucocorticoids could allow for dramatically lower steroid doses in the treatment of  Diamond Blackfan anemia and other erythropoietin-resistant anemias.

Image of cells with and without RUNX1 turned on

Scientists identify gene required for differentiation of breast stem cells

May 6, 2015

Scientists have applied a new method of analyzing cell states to identify a gene required for breast stem cells to differentiate. This gene, RUNX1, is deregulated or mutated in some leukemias and breast cancers. The novel approach, known as PEACS, could also be used to screen for drugs that activate or inhibit the expression regulators of stem cell differentiation.

Whitehead’s Susan Lindquist elected to UK’s Royal Society

May 1, 2015

The UK’s Royal Society today announced that it has elected Whitehead Institute’s Susan Lindquist as a Foreign Member.

Whitehead Founding Member Rudolf Jaenisch

Whitehead’s Rudolf Jaenisch honored with March of Dimes Prize

April 27, 2015

The prize honors Jaenisch’s groundbreaking body of work in epigenetics, the development of transgenic animals, and the generation and use of induced pluripotent stem (iPS) cells.

Image showing tumors

Imaging immunity: Noninvasive imaging of immune system detects tumors, could monitor therapeutic response

April 20, 2015

A novel approach that allows real-time imaging of the immune system’s response to the presence of tumors—without the need for blood draws or invasive biopsies—offers a potential breakthrough both in diagnostics and in the ability to monitor efficacy of cancer therapies.

Whitehead Member Jing-Ke Weng

Whitehead Member Jing-Ke Weng named a Searle Scholar

April 14, 2015

Whitehead Institute Member Jing-Ke Weng is among 15 young scientists nationwide to be named a 2015 Searle Scholar.

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