July 18, 2016
Whitehead Member Jing-Ke Weng is one of eight early-career scientists nationwide to be named a 2016 Beckman Young Investigator.
July 14, 2016
Whitehead Institute scientists have created a checklist that defines the “naive” state of cultured human embryonic stem cells (ESCs). Such cells provide a better model of early human embryogenesis than conventional ESCs in later stages of development.
July 4, 2016
MIT and Whitehead Institute scientists have developed a new type of easily customizable vaccine that can be manufactured in one week, allowing it to be rapidly deployed in response to disease outbreaks. So far, they have designed vaccines against Ebola, H1N1 influenza, and Toxoplasma gondii (a relative of the parasite that causes malaria), which were 100 percent effective in tests in mice.
June 20, 2016
Using tiny, alpaca-derived, single-domain antibody fragments, Whitehead Institute scientists have developed a method to perturb cellular processes in mammalian cells, allowing them to tease apart the roles that individual proteins play in these pathways. With improved knowledge of protein activity, scientists can better understand not only basic biology but also how disease corrupts cellular function and identify potential therapeutics to rectify these aberrations.
May 3, 2016
The National Academy of Sciences announced today that Whitehead Institute’s Hidde Ploegh and David Sabatini are among 84 new Academy members elected in recognition of distinguished and continuing achievements in original research.
April 29, 2016
Whitehead Institute scientists have determined that a plant protein involved in the timing of flowering could in fact be a prion. This is the first time that a possible prion has been identified in plants, and it may play a role in a plant’s “memory” of cold exposure during winter.
April 20, 2016
Using a novel method, Whitehead Institute researchers have determined how mutations that are not located within genes are identified through genome-wide association studies (GWAS) and can contribute to sporadic Parkinson’s disease, the most common form of the condition. The approach could be used to analyze GWAS results for other sporadic diseases with genetic causes, such as multiple sclerosis, diabetes, and cancer.
April 14, 2016
Whitehead Founding Member Robert Weinberg is one of two scientists to receive the prestigious Salk Institute Medal for Research Excellence, an honor that Salk has bestowed only twice before in its 55-year history.
April 5, 2016
The American Association for Cancer Research (AACR) announced today that Whitehead Institute Founding Member Rudolf Jaenisch is one of 11 newly elected Fellows of the AACR Academy.
March 10, 2016
Whitehead Institute researchers have elucidated how the growth-regulating metabolic pathway known as mTORC1 (for mechanistic target of rapamycin complex 1) senses the amino acid arginine. This nutrient sensor may represent a novel therapeutic target for controlling mTORC1, whose activity is often dysregulated in a variety of diseases, including diabetes and cancer.
March 3, 2016
In a finding with enormous implications for cancer diagnostics and therapeutics, Whitehead Institute scientists have discovered that breaches in looping chromosomal structures known as “insulated neighborhoods” can activate oncogenes capable of fueling aggressive tumor growth.
March 2, 2016
Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer. Now, a new study from Whitehead Institute and MIT’s Koch Institute for Integrative Cancer Research reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous.