Events

Symposium for Susan Lindquist

Susan Lindquist, Member and former Director of Whitehead Institute

Susan Lindquist in front of an image of yeast cells, which she used as living test tubes to study alpha-synuclein, the protein believe to be responsible for Parkinson's disease

Image: Sam Odgen/Whitehead Institute






Susan Lee Lindquist, Ph.D., Member and former Director of Whitehead Institute, and one of the nation’s most lauded scientists, succumbed to cancer on October 27, 2016. Her nearly 40-year career was defined by intellectually courageous, boundary-defying research and a passion for nurturing new generations of scientific talent. To honor her legacy, lab members and alumni, colleagues, and friends held a symposium on July 7th and 8th, 2017, at Whitehead Institute. Below is the event's program.

 


Friday, July 7


9:00 – 9:05 Welcome from Brooke Bevis and David Page


9:05 – 9:10 Session Chair: Luke Whitesell

9:10 – 9:30 Ruth Scherz-Shouval

Transcriptional rewiring by HSF1 in the tumor microenvironment - More multifaceted than we ever expected

9:30 – 9:50 Marc Mendillo

Exploiting heat shock factor addictions in malignancies

9:50 – 10:05 Peter Tsvetkov

A new way cancer cells cope with proteotoxic stress

10:05 – 10:20 Georgios Karras

Taming a great beast: protein homeostasis for precision health


10:20 – 10:40 Break


10:40 – 10:45 Session Chair: Vikram Khurana

10:45 – 11:05 Mikko Taipale

Studying 1,000 rare diseases at the same time

11:05 – 11:25 Walker Jackson

Molecular dissection approaches to study diseased tissues

11:25 – 11:40 Can Kayatekin

IAPP oligomers clog the ER translocon

11:40 – 12:00 Jiyan Ma

Molecular basis of prion infectivity


12:00 – 1:20 Lunch


1:20 – 1:25 Session Chair: Steve Henikoff

1:25 – 1:45 Jessica Brown

1 + 1 = 3: Rapid identification and rational design of synergistic small molecule combinations to treat microbial infections

1:45 – 2:05 Kent Golic

Ring chromosomes, chromosome breakage and fragile sites in Drosophila

2:05 – 2:25 Andy Steele

Knowing when it's (circadian) time to eat

2:25 – 2:45 Michael Welte

At the intersection of fat storage and protein homeostasis: Lipid droplets control histone availability in Drosophila embryos


2:45 – 3:05 Break


3:05 – 3:10 Session Chair: Joan Brugge

3:10 – 3:30 Chee-Yeun Chung

Yumanity: From yeast to neurons to patients

3:30 – 3:50 Tiago Outeiro

From the baker to the bedside: Unraveling the molecular basis of neurodegeneration

3:50 – 4:05 Aftabul Haque

Simple models for complex disorders: A yeast to neuron platform for unravelling Aβ cytotoxicity


4:05 – 4:25 Break


4:25 – 4:30 Session Chair: Rick Morimoto

4:30 – 4:50 James Shorter

Designing disaggregases

4:50 – 5:10 Heather True-Krob

Chaperone supervision of the protein folding dance

5:10 – 5:30 Simon Alberti

Organizing living matter: The role of phase transitions in cell biology and disease


5:30 – 6:30 Cocktail Hour, 2nd floor lobby of Whitehead Institute


6:30 – 8:30 Dinner, 1st floor Whitehead Institute

Brief remarks: James Shorter & Aaron Gitler, Nora Buckbee


saturDAY, JULY 8


9:00 – 9:05 Session Chair: Leona Samson

9:05 – 9:25 Leah Cowen

Transcriptional control coupling stress response, drug resistance, and cell cycle progression in fungal pathogens

9:25 – 9:45 Christine Queitsch

Chaperone Hsp90 facilitates trait decisions and protein evolution

9:45 – 10:05 Eric Schirmer

Multiple layers of gene regulation in development and disease enabled by tissue-specific nuclear envelope-genome tethering

10:05 – 10:25 Joseph Yost

Left-right asymmetry, cilia and congenital heart disease


10:25 – 10:45 Break


10:45 – 10:50 Session Chair: Jeffery Kelly

10:50 – 11:10 Daniel Jarosz

Remembering the past: A new form of protein-based inheritance

11:10 – 11:30 Kendra Frederick

Putting prions in context: Towards in vivo NMR

11:30 – 11:50 Liming Li

The [SWI+] prion

11:50 – 12:10 Randal Halfmann

Quantitative prion biology


12:10 – 1:35 Lunch


1:35 – 1:40 Session Chair: Carla Shatz

1:40 – 2:00 Aaron Gitler

Expanding mechanisms and therapeutic targets for neurodegenerative disease

2:00 – 2:20 Martin Duennwald

New yeast models of aging and oxidative stress

2:20 – 2:35 Priyanka Narayan

Beyond plaques and tangles: Deciphering Alzheimer's risk

2:35 – 2:55 Gabriela Caraveo-Piso

YEaSt WE CAN: from a single cell organism to a clinical trial


2:55 – 3:15 Break


3:15 – 3:20 Session Chair: Mina Bissell

3:20 – 4:00 Keynote Lecture: Elaine Fuchs

Susan, Sisters and Science


4:00 – 4:05 Closing Remarks: Christine Queitsch

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